Dr Christopher Talbot

Chris Talbot
Lecturer in Medical Genetics

Tel: +44 (0)116 252 3433
Fax: +44 (0)116 252 3378

Email: cjt14@le.ac.uk

BSc (Imperial College), PhD (London)

Personal details

BSc, PhD

I was born in Hong Kong, but went to school in High Wycombe, Buckinghamshire. After a BSc at Imperial College in London, I worked first at St. Mary’s Hospital in Paddington with John Hardy on the genetics of Alzheimer’s disease.I then carried out a PhD as an external student of London University, working at Washington University in St. Louis. The project, supervised by Alison Goate, continued the work on Alzheimer’s disease. Subsequently I returned to the UK to carry out a three-year postdoc with Jonathan Flint at the Wellcome Trust Centre for Human Genetics at Oxford University. This work in psychiatric genetics aimed to find quantitative trait loci for anxiety in mice. I obtained a lectureship in the Department of Genetics in the University of Leicester in 2001.

Websites

PubMed
Leicester Research Archive
Google Scholar

Other responsibilities

  • Module Convenor MB2051 and MB3050
  • Intercalated BSc committee and dept co-ordinator
  • Chair of Board of Examiners for MSc Molecular Genetics

Teaching

  • BS3031 (Human Genetics)
  • MB2051 (Current Issues in Medical Genetics)
  • MB3050 (Medical Genetics)

Publications

  • Hainsworth AH, Allsopp RC, Jim A, Potter JF, Lowe J, Talbot CJ, Prettyman RJ. Death-associated protein kinase (DAPK1) in cerebral cortex of late-onset Alzheimer's disease patients and aged controls. Neuropathol Appl Neurobiol. 2010 Feb;36(1):17-24.
  • Tanteles GA, Whitworth J, Mills J, Peat I, Osman A, McCann GP, Chan S, Barwell JG, Talbot CJ, Symonds RP. Can cutaneous telangiectasiae as late normal-tissue injury predict cardiovascular disease in women receiving radiotherapy for breast cancer? Br J Cancer. 2009 Aug 4;101(3):403-9.
  • Sandhu J, Kaur B, Armstrong C, Talbot CJ, Steward WP, Farmer PB, Singh R. Determination of 5-methyl-2'-deoxycytidine in genomic DNA using high performance  liquid chromatography-ultraviolet detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 1;877(20-21):1957-61.
  • Giotopoulos G, Armstrong C, Osman A, Peat I, Symonds RP, Talbot CJ. Refining the evidence for GSTA1 and eNOS genetic effects on risk of radiotherapy-induced telangiectasia. Int J Cancer. 2008 Dec 15;123(12):2973-4.
  • Jawad M, Cole C, Zanker A, Giotopoulos G, Fitch S, Talbot CJ, Plumb M. QTL analyses of lineage-negative mouse bone marrow cells labeled with Sca-1 and c-Kit. Mamm Genome. 2008 Mar;19(3):190-8.
  • Jawad M, Giotopoulos G, Fitch S, Cole C, Plumb M, Talbot CJ. Mouse bone marrow and peripheral blood erythroid cell counts are regulated by different autosomal genetic loci. Blood Cells Mol Dis. 2007 Mar-Apr;38(2):69-77.
  • Tarpey P, Thomas S, Sarvananthan N, Mallya U, Lisgo S, Talbot CJ, Roberts EO, Awan M, Surendran M, McLean RJ, Reinecke RD, Langmann A, Lindner S, Koch M, Jain S, Woodruff G, Gale RP, Degg C, Droutsas K, Asproudis I, Zubcov AA, Pieh C, Veal CD, Machado RD, Backhouse OC, Baumber L, Constantinescu CS, Brodsky MC, HunterDG, Hertle RW, Read RJ, Edkins S, O'Meara S, Parker A, Stevens C, Teague J, Wooster R, Futreal PA, Trembath RC, Stratton MR, Raymond FL, Gottlob I. Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus. Nat Genet. 2006 Nov;38(11):1242-4

Research

The laboratory has diversified away from Alzheimer’s disease, and now has interest in a range of medical conditions, with a focus on translational applications of genetics.

A central project is to find the genetic determinants of adverse reactions to radiotherapy in breast cancer. For this purpose we have recruited a large cohort of patients scored for toxicity and are carrying out genetic studies to find the genetic polymorphisms that influence risk. Genetic variants found will contribute to a future genetic test allowing oncologists to treat patients in a personalised fashion according to their genetic make-up.

We are extending this work into cervical and lung cancer, together with combined analyses of chemo- and radiotherapy.
Dr Paul Symonds is the clinical lead on the breast cancer project, Claire Esler on lung cancer.

Other projects include a collaboration with Indonesian researchers working on bone mineral density, with Irene Gottlob on nystagmus and Cristina Tufarelli on DNA methylation in radiation response.

Supervision

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Contact Details

Department of Genetics
University of Leicester

Adrian Building
University Road
Leicester
LE1 7RH
United Kingdom

Tel: +44 (0)116 252 3374
Fax: +44 (0)116 252 3378
E Mail: genetics@le.ac.uk

Head of Department
Professor Alison Goodall

Accessibility

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