Dr Ezio Rosato
Tel: +44 (0)116 252 3351
Fax: +44 (0)116 252 3378
Laurea in Scienze Biologiche (Universita’ di Padova)
Dottorato (Phd) in Genetica (Universita’ di Ferrara)
I was born and grew-up in Mestre (Italy), which is part of the Venetian “dry-land” (terraferma). I studied at the University of Padova for my first degree. After military service in Rome, I won a national competition and obtained a PhD scholarship in Genetics. Although my ‘Dottorato’ was awarded by the University of Ferrara, my laboratory work was carried out in the Department of Biology at the University of Padova and in the Department of Genetics at the University of Leicester. I moved to Leicester permanently in 1994.
BS2060 Research Skills (Genetics stream)
BS2066 Behavioural Neurobiology
Postgraduate Admissions Tutor
Seear P J, Tarling GA, Teschke M, Meyer B, Thorne MAS , Clark MS, Gaten E, Ezio Rosato (2009) Effects of simulated light regimes on gene expression in Antarctic krill (Euphausia superba Dana) Journal of Experimental Marine Biology and Ecology, 381: 57-64.
Sandrelli F., Costa R., Kyriacou C.P., Rosato E. (2008) Comparative analysis of circadian clock genes in insects. Insect Molecular Biology. 17: 447-463
Codd V., Dolezel D., Stehlik J., Piccin A., Garner K., Seth R., Straatman K., Louis E., Costa R., Sauman I., Kyriacou C.P., Rosato E. (2007). Circadian rhythm gene regulation in the housefly, Musca domestica. Genetics, 177: 1539-1551.
Tauber E, Zordan M, Sandrelli F, Pegoraro M, Daga A, Osterwalder N, Selmin A, Etournay R, Monger K, Rosato E, Costa R, Kyriacou CP. (2007). Natural selection favours a newly derived timeless allele in Drosophila melanogaster. Science, 316: 1895-1898.
Sandrelli F, Tauber E, Pegoraro M, Mazzotta G, Cisotto P, Landskron J, Stanewsky R, Piccin A, Rosato E, Zordan M, and Kyriacou CP Costa R. (2007). Molecular basis for natural selection at the timeless locus in Drosophila melanogaster. Science. 316: 1898-1900.
Rosato E, Kyriacou CP (2006) Analysis of locomotor activity rhythms in Drosophila. Nature Protocols, 1: 559-568
Collins BH, Dissel S, Gaten E, Rosato E, Kyriacou CP. (2005) Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila. Proc. Natl. Acad. Sci. USA, 102: 19021-19026
Dissel S, Codd V, Fedic R, Garner K, Costa R, Kyriacou CP, Rosato E (2004) A constitutively active Drosophila CRYPTOCHROME. Nature Neuroscience. 7: 834-840
Rosato E, Codd, V., Mazzotta, G, Piccin, A., Zordan, M., Costa, R. & Kyriacou, C.P. (2001) Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY. Current Biology 11: 909-917.
In my laboratory, we are interested in behaviour, namely those observable processes initiated by an animal in response to extrinsic and/or intrinsic changes to the environment.
Behaviour is a product of the brain, therefore, we use it as a convenient tool for the analysis of the nervous system.
Over the years my laboratory has been particularly involved in studying a complex behaviour, the circadian clock, in insects and in particular in the fruitfly Drosophila melanogaster.
We are interested in the genes that regulate the clock and we study them by characterising their function, by examining their evolution, and by analysing their expression. We are also engaged in understanding how clock neurons (neurons expressing clock genes) are organised and how circadian information flows through their network. More recently we have started analysing other complex behaviours such as learning and memory, courtship and sleep.
Another area of research we are pursuing is the study of biological rhythmicity in marine invertebrates. The marine environment is particularly complex as the interplay of circadian, lunar and tidal rhythms might influence the habitat of some species. We have analysed the circadian and tidal behaviour of the ragworm Nereis viriens and we are currently studying the circadian behaviour of Northern and Antarctic krill.