Research

The molecular pathogenesis of enteric bacteria

My research interests have focused predominantly on the molecular analysis of campylobacter jejuni and campylobacter coli with occasional excursions into other enteric pathogens.

 

Agar Plate
Agar Plate

Current areas of work include iron transport systems and their regulation, with a focus on a molecular and functional dissection of different uptake systems expressed by campylobacters during intestinal colonisation. This work extends to the investigation of the role of host stress hormones in facilitating intestinal colonisation. In addition, we have a long-standing interest in iron-responsive regulatory systems in campylobacters. Arising from past work on two-component regulator systems in campylobacters, the group  investigates chemotactic motility, specifically the Campylobacter-specific aspects of the signal transduction pathway.

 

As a consequence of our work on host stress and Campylobacter colonisation, we are involved in next-generation sequencing and array-based investigation of the avian microbiota with a view to defining the relationship between poultry production, microbiota development and susceptibility to Campylobacter colonisation. Finally, the microbiota work is one example of a recent excursion into other enteric pathogens; this work has expanded to include the analysis of the microbiome of patients suffering from Clostridium difficile-mediated antibiotic-associated diarrhoea.

 

Research Links

Search PubMed at the US National Library of Medicine for this author: Prof J. Ketley
Search Leicester Research ArchiveProf J. Ketley
Search Google ScholarProf J. Ketley 

 

 

 

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Contact Details

Department of Genetics
University of Leicester

Adrian Building
University Road
Leicester
LE1 7RH
United Kingdom

Tel: +44 (0)116 252 3374
Fax: +44 (0)116 252 3378
E Mail: genetics@le.ac.uk

Head of Department
Professor Alison Goodall

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