Professor Yuri E. Dubrova

Professor Yuri DubrovaProfessor of Genetics

Tel: +44 (0)116 252 5654
Fax: +44 (0)116 252 3378

Email: yed2@le.ac.uk

 

 

 

 

Personal details

  • BSc (Kiev), PhD (Moscow), DrSci (Moscow)

I grew up in Kiev, Ukraine and did my undergraduate degree in Biology at Kiev State University (Ukraine). My PhD and DrSci in Genetics are from the NI Vavilov Institute of General Genetics, Moscow. In 1994, I moved to Leicester.

I am

  • a member of the Research Team
  • Chair of the Safety Team

and am on the Radiation Protection Subcommittee.

Websites

Teaching

BS3061 Mutagenesis (camp-based, module convenor)

MB1005 Genes and Medicine (camp-based)

Publications

Sarapultseva EI, Igolkina JV, Tikhonov VN, Dubrova YE. 2014. The in vivo effects of low-intensity radiofrequency fields on the motor activity of protozoa. Intl. J. Radiat. Biol. 90, 262-267. PMID: 24266430

Dubrova YE. 2013. The transgenerational effects of parental exposure to mutagens in mammals. In: Stress-Induced Mutagenesis. D Mittelman ed. Springer, NY, pp. 243-255.

Abouzeid Ali HE, Barber RC, Dubrova YE. 2012. The effects of maternal irradiation during adulthood on mutation induction and transgenerational instability in mice. Mutat. Res. 732, 21-25. PMID: 22289278.

Voutounou M, Glen CD, Dubrova YE. 2012. The effects of methyl-donor deficiency on mutation induction and transgenerational instability in mice. Mutat. Res. 734, 1-4. PMID: 22569175.

Mughal SK, Myazin AE, Zhavoronkov LP, Rubanovich AV, Dubrova YE. 2012. The dose and dose-rate effects of paternal irradiation on transgenerational instability in mice. A radiotherapy connection. PLoS ONE 7, e41300. PMID: 22911775.

Glen CD, Dubrova YE. 2012. Exposure to anticancer drugs can result in transgenerational genomic instability in mice. Proc. Natl. Acad. Sci. USA 109, 2984-2988. PMID:22308437.

Hardwick RJ, Tretyakov MV, Dubrova YE. 2009. Age-related accumulation of mutations supports a replication-dependent mechanism of spontaneous mutation at tandem repeat DNA loci in mice. Mol. Biol. Evol. 26, 2647-2654. PMID: 19679753

Barber RC, Hardwick RJ, Shanks ME, Glen CD, Mughal SK, Voutounou M, Dubrova YE. 2009. The effects of in utero irradiation on mutation induction and transgenerational instability in mice. Mutat. Res. 664, 6-12. PMID: 19428375

Shanks M, Riou L, Fouchet P, Dubrova YE. 2008. Stage-specificity of spontaneous mutation at a tandem repeat DNA locus in the mouse germline. Mutat. Res., 641, 58-60. PMID: 18423770

Glen CD, Smith AG, Dubrova YE. 2008. Single-molecule PCR analysis of germ line mutation induction by anticancer drugs in mice. Cancer Res., 68, 3630-3636. PMID: 18483245

Dubrova YE, Hickenbotham P, Glen, CD, Monger K, Wong H-P, Barber RC. 2008. Paternal exposure to ethylnitrosourea results in transgenerational genomic instability in mice. Environ. Mol. Mutagen. 49, 308-311. PMID: 18366099

Miccoli L, Burr KL-A, Hickenbotham P, Friedberg EC, Angulo JF, Dubrova YE. 2007. The combined effects of xeroderma pigmentosum C deficiency and mutagens on mutation rates in the mouse germline. Cancer Res., 67, 4695-4699. PMID: 17510396

Burr KL-A, van Duyn-Goedhart A, Hickenbotham P, Monger K, van Buul PPW, Dubrova YE. 2007. The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline. Mutat. Res., 617, 147-151. PMID: 17331550

Hatch T, Derijck AAHA, Black PD, van der Heijden GW, De Boer P, Dubrova YE. 2007. Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice. Oncogene, 26, 4720–4724. PMID: 17237807

Dubrova YE, Ploshchanskaya OG, Kozionova OS, Akleyev AV. 2006. Minisatellite germline mutation rate in the Techa River population. Mutat. Res., 602, 74-82. PMID: 16959276

Barber RC, Hickenbotham P, Hatch T, Kelly D, Topchiy N, Almeida G, Jones GGD, Johnson GE, Parry JM, Rothkamm K, Dubrova YE. 2006. Radiation-induced transgenerational alterations in genome stability and DNA damage. Oncogene, 25, 7336-7342. PMID: 16751800

Burr KL-A, Smith AG, Dubrova YE. 2005. p53 deficiency does not affect mutation rate in the mouse germline. Oncogene, 24, 4315-4318. PMID: 15806156

Dubrova YE. 2005. Radiation-induced mutation at tandem repeat DNA loci in the mouse germline: Spectra and doubling doses. Radiat. Res., 163, 200-207. PMID: 15658896

Barber RC, Miccoli L, van Buul PPW, Burr KL-A, van Duyn-Goedhart A, Angulo JF, Dubrova YE. 2004. Germline mutation rates at tandem repeat loci in DNA-repair deficient mice. Mutat. Res., 554, 287-295. PMID: 15450426

Dubrova YE. 2003. Radiation-induced transgenerational instability. Oncogene, 22, 7087-7093. PMID: 14557814

Vilarino-Guell C, Smith AG, Dubrova YE. 2003. Germline mutation induction at mouse repeat DNA loci by chemical mutagens. Mutat. Res., 526, 63-73. PMID: 12714184

Dubrova YE, Grant G, Chumak AA, Stezhka VA, Karakasian AN. 2002. Elevated minisatellite mutation rate in the post-Chernobyl families from Ukraine. Am. J. Hum. Genet., 71, 801-809. PMID: 12226793

Barber R, Plumb MA, Boulton E, Roux I, Dubrova YE. 2002. Elevated mutation rates in the germline of first- and second-generation offspring of irradiated male mice. Proc. Natl. Acad. Sci. USA, 99, 6877-6882. PMID: 11997464

Dubrova YE, Bersimbaev RI, Djansugurova LB, Tankimanova MK, Mamyrbaeva ZZ, Mustonen R, Lindholm C, Hultén M, Salomaa S. 2002. Nuclear weapons tests and human germline mutation rate. Science, 295, 1037. PMID: 11834827

Research

My research interests focus on the analysis of germline mutation induction in humans and mice following exposure to ionising radiation, chemical mutagens and some anticancer drugs. My recent research has also involved transgenerational genomic instability manifesting in the offspring of exposed parents.

Projects


Professor Yuri Dubrova Lecture

Germline mutation induction in mice
The project involves the study on the effects of paternal irradiation on copy number variation in the mouse germline.

Mechanisms of transgenerational instability in mice
The project involves analysis of epigenetic mechanisms underlying transgenerational instability in the offspring of irradiated male mice. The work on this project involves a genome-wide profiling of gene expression and DNA methylation in the offspring of irradiated parents, as well as the study on the effects of low-dose parental irradiation on the manifestation of transgenerational instability.

Transgenerational genomic instability caused by anticancer drugs
The project aims to establish whether paternal exposure to mutagenic anticancer drugs results in long-term transgenerational changes in mutation rates in the mouse germline and somatic tissues.

The genetic and epigenetic effects of folic acid deficiency in mice
The project aims to analyse the long-term impact of a folate-deficient diet on genome stability, DNA methylation and gene expression in treated mice and their offspring.

Supervision

You can search FindaPhD.com for PhDs supervised by Professor Y. Dubrova.

Current PhD projects in Lab

  • Epigenetic Mechanisms of Transgenerational Instability in Mice
  • The effects of Folic Acid Deficiency on Genome Stability
  • The Dose and Dose-rate Effects on Transgenerational Instability in Mice
  • The Effects Maternal Irradiation on ESTR Mutation Induction and Transgenerational Instability in Mice

Share this page:

Contact Details

Department of Genetics
University of Leicester

Adrian Building
University Road
Leicester
LE1 7RH
United Kingdom
 

Tel: +44 (0)116 252 3374

Fax: +44 (0)116 252 3378

E Mail: genetics@le.ac.uk

 

Interim Head of Department

Professor Alison Goodall