Research

Raymond has research interests that are laboratory based and others that lie in the area of bioinformatics. The main laboratory work focuses on determining the genetic basis of premature ovarian insufficiency in a project that involves colleagues in the department and also at the Leicester Royal Infirmary.

Collagen Triple Helix

The bioinformatics research is his major focus, and Raymond is a partner in the European Commission 7th Framework-funded GEN2PHEN project which is building database components, tools and technologies to help integrate information pertaining to genome variation and human disease phenotype. Raymond's major contribution to this project has been the development of a new DNA reference sequence format, known as Locus Reference Genomic (LRG), which will aid in the curation of variant data in locus-specific databases (LSDBs). The LRG project is a joint venture with the European Bioinformatics Institute (EBI) and the National Centre for Biotechnology Information (NCBI) and full details can be found at the LRG web site.

LRG Logo

Raymond is also involved in the emerging Café RouGE project which is also part of GEN2PHEN. Café RouGE aims to provide a portal for the submission of gene variant data in a fashion that will enable the data to by queried and re-purposed for storage and further analysis in other database systems. Hence, it exists as an intermediary between data providers and data curators. This builds on existing expertise with LSDBs and involves collaboration with software companies and diagnostic laboratories.

Research Links

Search PubMed at the US National Library of Medicine for this author: Dr R. Dalgleish
Search Leicester Research Archive: Dr R. Dalgleish
Search Google Scholar: Dr R. Dalgleish