Group lead

Dr Douglas Tincello graduated in medicine from the University of Edinburgh in 1990. His early training was completed in Edinburgh, including 2 years working Medical Research Council Centre for Reproductive Biology. He completed his training in Merseyside where he developed his interest in urogynaecology. He took up his current position of Senior Lecturer in Urogynaecology at the University of Leicester in April 2002 and has now established a portfolio of clinical and laboratory based research in urogynaecology.

Group members

• Dr Evangelia (Evi) Bakali (Academic Clinical Fellow)
• Dr Anjum (Angie) Doshani (NHS Consultant Gynaecologist)
• Dr Ruth Elliott (Senior Experimental Officer)
• Dr Jyothi Kambhampati (Research Fellow)
• Mr Christopher Mayne (NHS Consultant Urogynaecologist)
• Dr Anthony Taylor (Lecturer) and lead of the Reproductive Endocrinology Research Group and Member of the Endocannabinoid Research Group and Gynaecology Endocrinology Research Group (UHL NHS Trust)
• Dr Jonathan Willets (Lecturer) and lead of the Molecular Cell Signalling Research Group and Member of the Endocannabinoid Research Group

Research interests

The prolapse and incontinence research group has established a strong international reputation for clinical and laboratory research. Specific areas of clinical research currently under investigation include:

• Evaluation of the efficacy and safety of botulinum toxin for treatment of detrusor overactivity in women
• An assessment of the clinical utility of urodynamic testing before the decision to perform surgery on women with symptoms of stress urinary incontinence, in collaboration with Mr Paul Hilton and the University of Newcastle, as coinvestigators in the INVESTIGATE-I study.
• Evaluation of the safety and efficacy of standard prolapse surgery compared with synthetic and biological mesh, as an investigator site for the PROSPECT study.

Specific areas of laboratory research include:

• Study of the function of the T1R taste receptor G-protein coupled receptor family in the rodent and human bladder, continuing recent work describing the presence of these receptors in the bladder for the first time.
• Study of the biology of endogenous cannabinoids within the human and rodent bladder, in collaboration with members of the Endocannabinoid Research Group, and with Dr Keith Brain and Dr Thelma Lovick at the University of Birmingham.

Research Publication Supplementary Material

JU11489 - The TVT World Registry: A Prospective Evaluation of the Safety and Efficacy of Three Suburethral Sling Insertion Approaches for Stress Urinary Incontinence in Women

Supplementary Tables (pdf)