Professor Karen Brown

Professor of Translational Cancer ResearchKaren Brown

Contact Details

  • Tel: 0116 223 1851
  • Email: kb20@le.ac.uk
  • Office: CSMM, Level 5 Offices, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE1 5WW

Education

  • B.Pharm, University of Bradford
  • MRPharmS, Royal Pharmaceutical Society of Great Britain
  • PhD in Pharmaceutical Chemistry, University of Bradford

Research Interests

Preclinical and early clinical development of novel cancer chemopreventive agents

  • Development of resveratrol, curcumin and anthocyanins.
  • Determining optimal intervention schedules – investigation of dose-response relationships for dietary and pharmacological doses of chemopreventive agents.
  • Development of long-term in vitro models for screening agents.
  • Application and evaluation of human stem cells as novel in vitro/in vivo approaches for assessing efficacy of chemopreventive agents.
  • Combining dietary chemopreventive agents with chemotherapeutic regimens for the treatment of cancer.

Identification and development of novel biomarkers of cancer risk, prognosis and chemopreventive/chemotherapeutic agent efficacy

  • Development of novel, sensitive and specific techniques for biomarker analysis (particularly LC-MS/MS and accelerator mass spectrometry based methods).
  • Assessment of DNA damage (global and specific lesions) as a biomarker of efficacy for chemopreventive agents and chemotherapeutic drugs in humans.
  • Determining the mechanisms of tamoxifen carcinogenesis in women and the role of tamoxifen DNA adduct formation in human tissues.
  • Assessing the biological significance of DNA damage induced by occupational/environmental exposure to the carcinogen ethylene oxide.
  • Development of novel, biomarker driven strategies towards personalized treatment of Chronic Lymphocytic Leukaemia.

Publications

To view Professor Brown's publications, please use the link below:

Publications

 

 

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Contact Details

Department of Cancer Studies & Molecular Medicine
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 258 7597
F: +44 (0) 116 258 7599
E: csmm@leicester.ac.uk