Professor Karen Brown

Professor of Translational Cancer ResearchKaren Brown

Contact Details

  • Tel: 0116 223 1851
  • Email: kb20@le.ac.uk
  • Office: CSMM, Level 5 Offices, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE1 5WW

Education

  • B.Pharm, University of Bradford
  • MRPharmS, Royal Pharmaceutical Society of Great Britain
  • PhD in Pharmaceutical Chemistry, University of Bradford

Research Interests

Preclinical and early clinical development of novel cancer chemopreventive agents

  • Development of resveratrol, curcumin and anthocyanins.
  • Determining optimal intervention schedules – investigation of dose-response relationships for dietary and pharmacological doses of chemopreventive agents.
  • Development of long-term in vitro models for screening agents.
  • Application and evaluation of human stem cells as novel in vitro/in vivo approaches for assessing efficacy of chemopreventive agents.
  • Combining dietary chemopreventive agents with chemotherapeutic regimens for the treatment of cancer.

Identification and development of novel biomarkers of cancer risk, prognosis and chemopreventive/chemotherapeutic agent efficacy

  • Development of novel, sensitive and specific techniques for biomarker analysis (particularly LC-MS/MS and accelerator mass spectrometry based methods).
  • Assessment of DNA damage (global and specific lesions) as a biomarker of efficacy for chemopreventive agents and chemotherapeutic drugs in humans.
  • Determining the mechanisms of tamoxifen carcinogenesis in women and the role of tamoxifen DNA adduct formation in human tissues.
  • Assessing the biological significance of DNA damage induced by occupational/environmental exposure to the carcinogen ethylene oxide.
  • Development of novel, biomarker driven strategies towards personalized treatment of Chronic Lymphocytic Leukaemia.

Publications

Latest publication:

Hong Cai, Edwina Scott, Abeer Kholghi, Catherine Andreadi, Alessandro Rufini, Ankur Karmokar, Robert G. Britton, Emma Horner-Glister, Peter Greaves, Dhafer Jawad, Mark James, Lynne Howells, Ted Ognibene, Michael Malfatti, Christopher Goldring, Neil Kitteringham, Joanne Walsh, Maria Viskaduraki, Kevin West, Andrew Miller, David Hemingway, William P. Steward, Andreas J. Gescher and Karen Brown. Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice. Science Translational Medicine  29 Jul 2015: Vol. 7, Issue 298, pp. 298ra117

Abstract link

Reprint link

To view Professor Brown's other publications, please use the link below:

Publications

 

 

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Contact Details

Department of Cancer Studies
Clinical Sciences Building
University of Leicester
Leicester Royal Infirmary
Leicester LE2 7LX

T: +44 (0) 116 258 7597
F: +44 (0) 116 258 7599
E: cancerstudies@le.ac.uk

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