Dr Martine Hamann

Tel:  0116 252 3074     Email:  mh86@le.ac.uk

Lecturer in Neurosciences

Medical Sciences Building

Room 331 (office); Room 347 (lab)

Sensorineural hearing loss results from damage to the hair cells within the cochlea or to the auditory nerve (or both). Damage to the cochlea occurs naturally as part of the ageing (presbycusis) but other main factors cause sensorineural hearing loss such as regular and prolonged exposure to loud sounds or loud music; ototoxic drugs (certain types of antibiotics); infectious diseases (rubella); complication at birth or brain injuries; tumours on the auditory nerve; genetic predisposition. Sensorineural hearing loss is for the moment irreversible and cannot be cured as damaged cochlear hair cells remain damaged for the rest of a person’s life. Projects in the lab. involve identifying neuronal markers that are modulated after acoustic over exposure and target those markers with pharmacological and non pharmacological means.

High voltage activated potassium currents, targets against hearing loss or tinnitus?

Pilati et al., Hearing Research 283 (2012) pages 98-106

This publication shows that exposure to loud sound triggers hearing loss and this is correlated with profound changes in the first relay in the central auditory pathway (the dorsal cochlear nucleus).  Bursts observed in fusiform cells in this structure (figure below) are related to a down regulation of high voltage activated potassium currents.  Bursts could underlie the abnormal hyperexcitability observed in the central auditory system during tinnitus.

 

 

Martine Hamann - Image 3a

 

http://www.ncbi.nlm.nih.gov/pubmed/22085487

http://globalmedicaldiscovery.com/key-scientific-articles/acoustic-over-exposure-triggers-burst-firing-in-dorsal-cochlear-nucleus-fusiform-cells/

Past group members:

Nadia Pilati - PhD   GlaxoSmithKline

Present group members:

Matthew Barker

Thomas Tagoe - PhD  RNID

Julie Bourgognon

Publications relevant to the current projects :

Barker M, Billups B. and  Hamann M. (2009)  Focal macromolecule delivery in neuronal tissue using simultaneous pressure ejection and local electroporation. J. Neurosci. Methods 15:273-84.
Pilati N, Barker M, Panteleimonitis S, Donga R. and Hamann M. (2008) A rapid method combining Golgi and Nissl staining to study neuronal morphology and cytoarchitecture. J Histochem Cytochem. 56:539-550.
Song P, Yang Y, Barnes-Davies M, Bhattacharjee A, Hamann M, Forsythe ID, Oliver DL and Kaczmarek LK. (2005) Acoustic environment determines phosphorylation state of Kv3.1 potassium channel in auditory neurons. Nat. Neurosci. 8: 1335-1342.
Hamann M., Billups B. and I. F. Forsythe (2003) Non-calyceal excitatory inputs mediate low fidelity synaptic transmission in rat auditory brainstem slices. Eur. J. Neurosci. 18: 2899-2902.

Other publications :

Hamann M., Gibson A., Davies N., Walhin J.P., Partington L., Trezise D. And Main M. (2009). Human ClCla1 modulates anion conduction of calcium activated chloride currents. J. Physiol. (Lond.) 15: 2255-74.
Furness DN, Dehnes Y, Akhtar AQ, Rossi DJ, Hamann M, Grutle NJ, Gundersen V, Holmseth S, Lehre KP, Ullensvang K, Wojewodzic M, Zhou Y, Attwell D, Danbolt NC.(2008) A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2). Neuroscience 157: 80-94.
Hamann M., Rossi D.J., Mohr C., Andrade A.L. and D. Atwell (2005) The electrical response of cerebellar Purkinje neurons to simulated ischaemia. Brain. 128: 2408-2420.
P. Cavelier, M. Hamann, D. Rossi, P. Mobbs and D. Attwell (2005) Tonic excitation and inhibition of neurons: ambient transmitter. Sources and computational consequences.  Prog. Biophys. Mol. Biol. 87:3-16.
Rossi DJ, Hamann M and Attwell D. (2003) Multiple transmitter release modes activate GABA-A receptors in cerebellar granule cells. J. Physiol.(Lond.) 548: 97-110.
Hamann M., Rossi D.J. and D. Attwell (2002) Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. Neuron 33, 625-633.
Hamann M., Rossi D.J., Marie H. and D. Attwell (2002) Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia. Eur. J. Neurosci. 15: 1-8.

Useful links:

Action on Hearing Loss:
http://www.actiononhearingloss.org.uk/

Fact sheets about tinnitus can be downloaded at:
http://www.actiononhearingloss.org.uk/supporting-you/factsheets-and-leaflets.aspx

Deafness Research UK
http://www.deafnessresearch.org.uk/

American Tinnitus Association
http://www.ata.org/

Test your hearing 
http://www.audiocheck.net/audiotests_frequencycheckhigh.php

http://www.phys.unsw.edu.au/jw/hearing.html

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Contact Details

Department of Cell Physiology and Pharmacology,
College of Medicine, Biological Sciences and Psychology
University of Leicester,
Maurice Shock Medical Sciences Building,
University Road,
P.O. Box 138,
Leicester LE1 9HN

General Email: cpp@le.ac.uk

For individual email addresses,
see People or Research links.

Tel: +44 (0)116 252 3088
Fax: +44 (0)116 252 5045