|Current Research Areas|
The Biological Chemistry research group collaborate as members of the Centre for Chemical Biology, comprising of staff from the Departments of Biochemistry and Chemistry. The Centre uses a wide range of chemical approaches and ideas, including molecular structure and modelling, spectroscopy, kinetics and synthesis in a variety of research areas.
Further details of the current research areas of Molecular Enzymology, Structural Biology and Synthetic Chemistry can be found below.
We use kinetic, spectroscopic, potentiometric, single molecule imaging and protein engineering methods to study the mechanisms of a number of redox enzymes and motor proteins. Target enzymes include novel proteins identified from genome sequencing projects in addition to more established enzyme systems. The techniques are used in close collaboration with structural biology and computer modelling studies within the Centre for Chemical Biology.
Biological questions addressed
- Hydrogen tunnelling in enzymes - spearheading a major paradigm shift
- Mechanisms of biological electron transfer
- Mechanism of muscle contraction
- Behaviour of enzymes at the single molecule level
- Mechanisms of the cytochrome P450 enzymes
- Mechanism and function in haem (non-P450)-dependent enzymes
- Mechanisms of flavin-dependent enzymes
- Mechanisms of quinone-dependent enzymes
We use the techniques of X-ray crystallography and NMR spectroscopy to study the structure, dynamics and interactions of biological macromolecules, principally proteins. This work is carried out in close conjunction with functional studies of the proteins, so as to explore structure-function relationships, and also often with computer modelling studies.
Enzyme structure and function studies
Substrate binding and electron transfer in redox proteins, including:
- Cytochrome P450 mono-oxygenase system Morphinone reductase PETN reductase Fumarate reductase ETF
- O6Methylguanine-DNA methyltransferase - a DNA repair protein
- Inhibitor binding to metallo-b-Lactamases
- b-helical acyl-transferases
- Dihydrofolate reductase
We use synthetic chemistry to study biological processes at the molecular level. The techniques are used in close collaboration with structural biology, molecular enzymology and computer modelling studies within the Centre for Chemical Biology.
Biological questions addressed:
- Molecular recognition
- Protein-protein interactions
- Cell transport mechanisms
- Enzyme mechanisms and inhibition
Chemical Biology Group - Chemistry Academic Staff Members Contact Details:
|Prof. Paul M Cullis||+44 (0)116 252 firstname.lastname@example.org|
|Prof. Emma Raven||+44 (0)116 229 email@example.com|
|Dr Andrew J. Hudson||+44 (0)116 252 firstname.lastname@example.org|
|Dr Paul R. Jenkins||+44 (0)116 252 email@example.com|
|Dr Bernard Rawlings||+44 (0)116 252 firstname.lastname@example.org|
|Dr Mark P. Lowe||+44 (0)116 252 email@example.com|
|Dr Sandeep Handa||+44 (0)116 252 firstname.lastname@example.org|
|Dr Andrew Jamieson||+44 (0)116 252 email@example.com|
|General Enquiries||+44 (0)116 252 firstname.lastname@example.org|
Please use the links provided for individual staff members to find further details of their current research.