Lecturer in Organic Chemistry

BSc , PhD (Glasgow) 

Tel: 0116 252 2105

email: andrew.jamieson@le.ac.uk

My research interests are at the interface of synthetic organic and biological chemistry with current emphasis on the design and synthesis of small molecule mimics of protein secondary and tertiary structure. These molecules are then used as molecular probes to study protein-protein interactions involved in human diseases.

Research Group Web Site

Selected Publications

1. A 1,3-Phenyl-Linked Hydantoin Oligomer Scaffold as a ß-Strand Mimetic. A. G. Jamieson, D. Russell, A. D. Hamilton, Chem. Commun., 2012, 48, 3709 - 3711.
2. α-Amino-β-Hydroxy-γ-Lactam for Constraining Peptide Ser and Thr Residue Conformation. D. J. Saint-Cyr, A. G. Jamieson, W. D. Lubell, Org. Lett., 2010, 12, 1652-1655.
3. Structure-Activity Analysis of the Growth Hormone Secretagogue GHRP-6 by α- and β-Amino γ-Lactam Positional Scanning. N. Boutard, A. G. Jamieson, H. Ong, W. D. Lubell, Chem. Biol. Drug Des., 2010, 75, 40-50.
4. Positional Scanning for Peptide Secondary Structure by Systematic Solid-Phase Synthesis of Amino Lactam Peptides. A. G. Jamieson, N. Boutard, K. Beauregard, M. S. Bodas, H. Ong, C. Quiniou, S. Chemtob, W. D. Lubell, J. Am. Chem. Soc., 2009, 131, 7917-7927.
5. Ether-Directed, Stereoselective Aza-Claisen Rearrangements: Synthesis of the Piperidine Alkaloid, α-Conhydrine. A. G. Jamieson, A. Sutherland, Org. Lett., 2007, 9, 1609-1611.
6. Stereoselective β-Hydroxy-α-Amino Acid Synthesis via an Ether-Directed, Palladium-Catalysed, aza-Claisen Rearrangement. K. N. Fanning, A. G. Jamieson, A. Sutherland, Org. Biomol. Chem., 2005, 3, 3749-3756.