Our group study signalling mechanisms and are particularly interested in growth factors and the receptor tyrosine kinase family of proteins. Much of our work focuses on the angiopoietins and their receptors. We aim to understand the molecular basis for how these and other receptors control tissue growth, regeneration, regression and function. In addition, we are developing molecular approaches to manipulate these signalling mechanisms for therapeutic control of tissue growth.

Our work is relevant to diseases involving vascular dysfunction, such as atherosclerosis, stroke and vascular inflammation, as well as angiogenesis, regenerative medicine and tissue engineering.

We use a wide range of approaches, including cell and molecular techniques, protein engineering, phage display, yeast two-hybrid analysis and RNA interference.