Personal tools
Contact the Department

Department of Cardiovascular Sciences
University of Leicester
Clinical Sciences Wing
Glenfield General Hospital
Leicester
LE3 9QP

General Enquiries to
Louise Goddard
Tel: 0116 258 3045

Postgraduate General Enquiries to
Postgraduate Tutor

For other contact details see under
Research Groups
People A-Z

 

Selected Publications

Hansen, TM, Singh, H, Tahir, TA & Brindle NPJ (2010) “Effects of Angiopoietin-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface” Cellular Signalling 22 527-532.

Moss, AJ, Sharma S & Brindle, NPJ (2009) “Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering” Biochemical Society Transactions 37 717-721.

Singh, H, Milner, CS, Aguilar Hernandez, MM, Patel, N & Brindle NPJ (2009) “Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases” Cellular Signalling 21 1346-1350. 

Marron, MB, Singh, H, Tahir, TA, Kavumkal, J, Kim, H-Z, Koh, GY & Brindle, NPJ (2007) "Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor tyrosine kinase Tie2" Journal of Biological Chemistry 282 30509-30517. PDF

Rees, KA, Singh, H & Brindle, NPJ (2007) “The receptor tyrosine kinase Tie1 is expressed and activated in epithelial tumour cell lines” International Journal of Oncology 31 893-897.

Brindle, NPJ, Saharinen, P & Alitalo, K (2006) “Signalling and functions of Angiopoietin-1 in vascular Protection” Circulation Research 98 1014-1023. PDF

Saharinen, P., Kerkela, K., Ekman, N., Marron, M., Brindle, N., Lee, G.M., Augustin, H., Koh, G.Y. and Alitalo, K. (2005). "Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2" Journal of Cell Biology 169 239-243. PDF

Gill, KA & Brindle, NPJ (2005) "Angiopoietin-2 stimulates migration of endothelial progenitors and their interaction with endothelium" Biochemical and Biophysical Research Communications 336 392-396.

Morris, P.N., Dunmore, B.J., Tadros, A., Marchuk, D.A., Darland, D.C., D'Amore, P.A. & Brindle, NPJ (2005). "Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations" Journal of Molecular Medicine 83 58-63. PDF

Tadros, A, Hughes, DP, Dunmore, BJ & Brindle NPJ (2003) "ABIN-2 protects endothelial cells from death and has a role in the anti-apoptotic effect of angiopoietin-1" Blood 102 4407-4409. 

Hughes, DP, Marron, MB & Brindle, NPJ (2003) “The Antiinflammatory Endothelial Tyrosine Kinase Tie2 Interacts With a Novel Nuclear Factor-kB Inhibitor ABIN-2” Circulation Research 92 630-636. PDF

Cotton, JM, Thomas, MR, Dunmore, BD, Salisbury, JR, Shah, AM & Brindle, NPJ (2002) “Angiogenesis in chronically ischaemic human heart following percutaneous myocardial revascularisation” Heart 87 281-283.

Tsiamis AC, Morris PN, Marron MB & Brindle NPJ (2002) “Vascular endothelial growth factor modulates the Tie-2:Tie-1 complex” Microvascular Research 63 149-158.

Price, CJ & Brindle, NPJ (2000) "Involvement of the vasodilator-stimulated phosphoprotein VASP in formation of stress-fibres and membrane ruffling in endothelial cells" Arteriosclerosis, Thrombosis and Vascular Biology, 20 2051-2056. PDF

Marron, MB, Hughes, DP, Edge, MD, Forder, CL & Brindle, NPJ (2000) "Evidence for heterotypic interaction between the receptor tyrosine kinases Tie-1 and Tie-2" Journal of Biological Chemistry 275 39741-39746. PDF

Contact details

Nick Brindle

University of Leicester
Department of Cardiovascular Science
RKCSB, PO Box 65
Leicester LE2 7LX UK

Tel:       +44 (0)116 252 5802

Fax:       +44 (0)116 252 3179

Email:   npjb1@le.ac.uk

 

PA: Sandie Smith

Tel:         +44(0) 116 252 3252

Email:        sms16@le.ac.uk