Research includes physiological studies of vascular structure and function in patients with vascular disease, hypertension or diabetes; the use of biomarkers such as the natriuretic peptides for diagnosing, and predicting the prognosis of, heart failure and ischemic heart disease, and the discovery and validation of new markers using proteomics and metabolomics; studies of carotid artery disease including optimisation of endarterectomy procedures and regulation of thrombotic factors; the applications of physical science to cardiovascular diseases including vascular measurement technology (including Doppler ultrasound and continuous blood pressure measurement); cardiovascular monitoring (including embolus detection; real-time data acquisition and dynamic analysis of arterial wall motion); blood flow and perfusion measurements in the heart and brain; blood flow autoregulation and its impairment in cardiovascular disease and physiological modelling; magnetic resonance measurements of myocardial function and pathophysiology; autonomic modulation of cardiac excitation; pathophysiology of atrial and ventricular fibrillation; catheter ablation techniques.