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Department of Cardiovascular Sciences
University of Leicester
Clinical Sciences Wing
Glenfield General Hospital
Leicester
LE3 9QP

General Enquiries to
Louise Goddard
Tel: 0116 258 3045

Postgraduate General Enquiries to
Postgraduate Tutor

For other contact details see under
Research Groups
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Professor Bryan Williams

Professor B Williams

Professor of Medicine, University of Leicester and Honorary Consultant Physician, University Hospitals of Leicester NHS Trust, April 1996-present (HEFCE)

BSc Hons First Class, 1980, University of London
MB BS, 1983, St. Mary's Hospital Medical School, University of London
MRCP, 1986, Royal College of Physicians, London
FRCP, 1995, Royal College of Physicians, London
MD (Distinction), 1996, University of Leicester
FAHA, 2001, American Heart Association
President, British Hypertension Society 2001-2003
Deputy Director, Leicester NIHR Biomedical Research Unit in Cardiovascular Diseases 2009-

Tel: 0116 258 3032

Email: bw17@le.ac.uk

Address:  Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester LE3 9QP

For general enquiries, please email Mrs Sue Page, Personal Assistant, or telephone 0116 258 3031

Research Interests

  • Hypertension (basic and pathophysiological studies)

  • Diabetic, cardiovascular and renal disease (basic, clinical and cell biological studies)

  • Molecular and cellular aspects of cardiovascular injury and ageing with particular reference to the role of the renin-angiotensin system, hypertension and metabolic factors

  • Cardiovascular Risk management

External Positions

President, British Hypertension Society 2001-2003
Chairman British Hypertension Society Guidelines development group 2003-
Chairman, Medical Research Council, Clinical Training Fellowship Award Panel, Clinician Scientist Award Panel and Senior Clinician Scientist Award Panel Chairman, Department of Health/MRC, Clinician Scientist Panel.
Member of the British Heart Foundation Project Grants Committee, 2000-2002.
Clinical Professors Representative, GIM, SAC-JCMHT, RCP London
Member, European Society Hypertension Education and Specialist Accreditation Committee
Associate Editor & Editorial Board of Journal of Hypertension: 1999 - present
Clinical Science, Associate Editor for Cardiovascular Section 2000-2002
Chairman, NICE Hypertension Guideline Development Group 2009 - 2011

Key Publications

Williams B, Lacy PS; CAFE and the ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Investigators. Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) Study: CAFE-Heart Rate. J Am Coll Cardiol. 2009 Aug 18 54 8 705-13

Williams B, Lacy PS, Cruickshank JK, Collier D, Hughes AD, Stanton A, Thom S, Thurston H; CAFE and ASCOT Investigators. Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study. Circulation. 2009 Jan 6 119 1 53-61

Williams B, Lindholm LH, Sever P. Systolic pressure is all that matters. Lancet. 2008 Jun 28 371 9631 2219-21

ADVANCE Collaborative Group, Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan  Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008 Jun 12 358 24 2560-72

Williams B. The year in hypertension. J Am Coll Cardiol. 2008 May 6 51 18 1803-17

ONTARGET Investigators, Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P, Anderson C.Williams B et al Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008 Apr 10 358 15 1547-59

Herbert KE, Mistry Y, Hastings R, Poolman T, Niklason L, Williams B. Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways. Circ Res. 2008 Feb 1 102 2 201-8

Patel A; ADVANCE Collaborative Group, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. 2007 Sep 8 370 9590 829-40

Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet. 2007 Aug 18 370 9587 591-603

Williams B, Lacy PS, Thom SM, Cruickshank K, Stanton A, Collier D, Hughes AD, Thurston H, O'Rourke M; CAFE Investigators; Anglo-Scandinavian Cardiac Outcomes Trial Investigators; CAFE Steering Committee and Writing Committee. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation. 2006 Mar 7 113 9 1213-25

Links

Full list of papers 2011-2006

Papers before 2006

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