Dr Maciej Tomaszewski

Maciej Tomaszewski

Clinical Senior Lecturer in Cardiovascular Medicine &
Honorary Consultant Physician

BSc Honours, Medical University of Silesia, Poland (1998)
MD, Honours, Medical University of Silesia, Poland (1999)
FAHA, USA 2005
FRCP, London 2012
 

Tel: 0116 204 4752

Email: mt142@le.ac.uk

Address: Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield General Hospital, Leicester, LE3 9QP

For general enquiries please email the secretary, Louise Goddard, or telephone 0116 256 3045.

Research Interests

My research interests focus primarily on genetics and genomics of cardiovascular disorders with a particular emphasis on essential hypertension and its complications.

I am also interested in genetic and environmental background of sexual dimorphism in cardiovascular risk (why men develop and die of cardiovascular disorders more frequently than age-matched women).

Editorials Boards

Clinical Science - Member of the Editorial Advisory Panel 2007-
Gender Medicine – Associate Editor (Cardiovascular Section) 2010-12
Hypertension - Member of the Editorial Board 2011-
Journal of Hypertension - Editorial Board member 2013-

External positions

Chair of International Society of Hypertension New Investigator Committee 2013 -
Member of International Society of Hypertension Membership Committee 2011 -
Member of International Society of Hypertension Awards Committee 2011-

Key Publications

Bloomer LD, Nelson CP, Eales J, Denniff M, Christofidou P, Debiec R, Moore J, Consortium C, Zukowska-Szczechowska E, Goodall AH, Thompson J, Samani NJ, Charchar FJ, Tomaszewski M. Male-specific region of the Y chromosome and cardiovascular risk: phylogenetic analysis and gene expression studies. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1722-7

Charchar FJ, Bloomer LD, Barnes TA, Cowley MJ, Nelson CP, Wang Y, Denniff M, Debiec R, Christofidou P, Nankervis S, Dominiczak AF, Bani-Mustafa A, Balmforth AJ, Hall AS, Erdmann J, Cambien F, Deloukas P, Hengstenberg C, Packard C, Schunkert H, Ouwehand WH, Ford I, Goodall AH, Jobling MA, Samani NJ, Tomaszewski M. Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet. 2012 Mar 10;379(9819):915-22

Tomaszewski M, Charchar FJ, Nelson CP, Barnes T, Denniff M, Kaiser M, Debiec R, Christofidou P, Rafelt S, van der Harst P, Wang WY, Maric C, Zukowska-Szczechowska E, Samani NJ. Pathway analysis shows association between FGFBP1 and hypertension. J Am Soc Nephrol. 2011 May;22(5):947-55.

Tomaszewski M, Debiec R, Braund PS, Nelson CP, Hardwick R, Christofidou P, Denniff M, Codd V, Rafelt S, van der Harst P, Waterworth D, Song K, Vollenweider P, Waeber G, Zukowska-Szczechowska E, Burton PR, Mooser V, Charchar FJ, Thompson JR, Tobin MD, Samani NJ. Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array. Hypertension. 2010 Dec;56(6):1069-76.

Tomaszewski M, Charchar FJ, Barnes T, Gawron-Kiszka M, Sedkowska A, Podolecka E, Kowalczyk J, Rathbone W, Kalarus Z, Grzeszczak W, Goodall AH, Samani NJ, Zukowska-Szczechowska E. A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterolArterioscler Thromb Vasc Biol. 2009 Sep 29 9 1316-21

Kaess BM, Jozwiak J, Mastej M, Lukas W, Grzeszczak W, Windak A, Piwowarska W, Tykarski A, Konduracka E, Rygiel K, Manasar A, Samani NJ, Tomaszewski M. Association between anthropometric obesity measures and coronary artery disease - a cross-sectional survey of 16,657 subjects from 444 Polish citiesHeart. 2010 Jan;96(2):131-5. Epub 2009 Aug 2

Tomaszewski M, Charchar FJ, Maric C, Kuzniewicz R, Gola M, Grzeszczak W, Samani NJ, Zukowska-Szczechowska E. Association between lipid profile and circulating concentrations of estrogens in young menAtherosclerosis. 2009 Mar 203 1 257-62

Tobin MD, Tomaszewski M, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR, Samani NJ. Common Variants in Genes Underlying Monogenic Hypertension and Hypotension and Blood Pressure in the General PopulationHypertension. 2008 Jun 51 6 1658-64

Tomaszewski M, Charchar FJ, Lynch MD, Padmanabhan S, Wang WY, Miller WH, Grzeszczak W, Maric C, Zukowska-Szczechowska E, Dominiczak AF. Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis. Circulation. 2007 Oct 23 116 17 1915-24

Tomaszewski M, Charchar FJ, Maric C, McClure J, Crawford L, Grzeszczak W, Sattar N, Zukowska-Szczechowska E, Dominiczak AF. Glomerular hyperfiltration: a new marker of metabolic riskKidney Int. 2007 Apr 71 8 816-21

Tomaszewski M, Zimmerli L, Charchar FJ, Dominiczak AF. Genetic information in the diagnosis and treatment of hypertensionCurr Hypertens Rep. 2006 Aug 8 8 309-16

Tomaszewski M, Charchar FJ, Lacka B, Pesonen U, Wang WY, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertensionHypertension. 2004 Nov 44 5 689-94

Tomaszewski M, Charchar FJ, Przybycin M, Crawford L, Wallace AM, Gosek K, Lowe GD, Zukowska-Szczechowska E, Grzeszczak W, Sattar N, Dominiczak AF. Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go? Arterioscler Thromb Vasc Biol. 2003 Sep 1 23 9 1640-4

Tomaszewski M, Brain NJ, Charchar FJ, Wang WY, Lacka B, Padmanabahn S, Clark JS, Anderson NH, Edwards HV, Zukowska-Szczechowska E, Grzeszczak W, Dominiczak AF. Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. Hypertension. 2002 Sep 40 3 286-91

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Contact the Department

Department of Cardiovascular Sciences
University of Leicester
Clinical Sciences Wing
Glenfield General Hospital
Leicester
LE3 9QP

General Enquiries to
Louise Goddard
Tel: 0116 258 3045

Postgraduate General Enquiries to
Postgraduate Tutor

For other contact details see under
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