Professor Iain B Squire
Professor of Cardiovascular Medicine, University of Leicester & Honorary Consultant Physician, University Hospitals of Leicester
B.Sc. (Biochemistry and Pharmacology, Joint Honours)(1st Class) Strathclyde, 1982
M.B.,Ch.B. Glasgow, 1987
M.R.C.P. (UK) 1991
M.D. Glasgow, 1997
F.R.C.P. (London) 2002
Tel: 0116 258 3041 Email: is11@le.ac.uk
Address: Pharmacology and Therapeutics Group, Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP
For general enquiries, please email Carolyn Carvell, secretary, or telephone 0116 250 2348
Research Interests
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Natriuretic peptides and other peptide markers in heart failure
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Epidemiology of heart failure
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Matrix metalloproteinases as markers of prognosis in ACS
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Advanced nursing issues in the management of heart failure
Other Academic Distinctions
UK co-ordinator of a Europe-wide Cardiac Resynchronisation Registry, on behalf of the Heart Failure Association and Heart Rhythm Society of the European Society of Cardiology. July 2008-current
Editorial boards : British Journal of Clinical Pharmacology International Editorial Board, 2000-2004
Clinical Science Editorial Advisory Board August 2006-current
Myocardial Infarction National Audit Project (MINAP) Academic Group (MAG); invited membership June 2008-current
Current Treasurer of British Society for Heart Failure (elected by Society Members)
Councillor, British Society for Heart Failure 2003-2005 (elected by Society Members); British Pharmacological Society, Clinical Section Committee, December 2000-2004
Key Publications
Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, Horrow J, Husted S, James S, Katus H, Mahaffey KW, Scirica BM, Skene A, Steg PG, Storey RF, Harrington RA; PLATO Investigators, Freij A, Thorsén M. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009 Sep 10;361(11):1045-57
Kelly D, Cockerill G, Ng LL, Thompson M, Khan S, Samani NJ, Squire IB. Plasma Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after Acute Myocardial Infarction. European Heart Journal 2008; doi:10.1093/eurheartj/ehn315.
Kelly D, Cockerill G, Ng LL, Thompson M, Samani NJ, Squire IB. Circulating Stromelysin-1 (MMP-3): a novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction. Eur. J. Heart Failure 2008; 10: 133-9. (Epub 2008 Jan 30)
Nelson CP, Lambert PC, Squire IB, Jones DR. Relative Survival - What Can Cardiovascular Disease Learn From Cancer ? Eur. Heart J. 2008; 29: 941-7 (Epub Mar 6. 2008; doi: 10.1093/eurheartj/ehn079)
Kelly D, Cockerill G, Ng LL, Thompson M, Khan S, Samani NJ, Squire IB. Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study. European Heart Journal 2007; doi: 10.1093/eurheartj/ehm003
Ng LL, Loke IW, Davies JE, Geereanavar S, Khunti K, Stone MA, Chin DT, Squire IB. Community screening for left ventricular systolic dysfunction using plasma and urinary natriuretic peptides. J Am Coll Cardiol. 2005; 45: 1043-50
Blackledge HM, Newton J, Squire IB. Prognosis for South Asian and white patients newly hospitalised with heart failure in the UK: A historical cohort study. BMJ 2003; 327: 526-531
Squire IB, O’Kane KPJ, Anderson N, Reid JL. Bradykinin B2 receptor antagonism attenuates the blood pressure response to acute ACE inhibition in normal man. Hypertension; 2000; 36: 132-136
Squire IB, Lawley WJ, Fletcher S, Holme E, Hillis WS, Hewitt C, Woods KL. Humoral and cellular immune responses up to 7.5 years after administration of streptokinase for acute myocardial infarction. Eur.Heart J, 1999; 20: 1245-1252
Muir KW, Squire IB, Alwan W, Reid JL. Anticardiolipin antibodies in an unselected stroke population. Lancet 1994 344: 452-456
Links
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