Professor of Medicine & Therapeutics, University of Leicester and Honorary Consultant Physician, Cardiovascular Unit, University Hospitals of Leicester NHS Trust

BA (Medical Sciences Tripos (1st Class), Cambridge, 1976
MB B Chir (Distinction), Cambridge, 1979
MRCP (UK), London, 1982
MD, Cambridge, 1988
FRCP, London, 1996

Tel: 0116 252 3132

Email: lln1@le.ac.uk

Address: Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX

For general enquiries, please email the Secretary, Mrs Val Thomas, or telephone 0116 252 3126

Research Interests

• Studies on the role of cardiovascular peptides in heart disease

• The use of hormonal markers for diagnosis and prognosis in heart disease and to determine therapeutic response to various drug treatments

• Use of proteomic technologies in biomarker discovery

External Positions

External Examiner for PhD, MD (Universities of Oxford, Manchester, Birmingham, London, Melbourne)

Editorial Advisory Board, Clinical Science

Secretary and Member of SAC, Clinical Pharmacology and Therapeutics

Key Publications

Khan SQ, Ng K, Dhillon O, Kelly D, Quinn P, Squire IB, Davies JE, Ng LL.  Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction.  Eur Heart J. 2009 May;30(9):1057-65

Khan SQ, Dhillon O, Kelly D, Squire IB, Struck J, Quinn P, Morgenthaler NG, Bergmann A, Davies JE, Ng LL. Plasma N-terminal B-Type natriuretic peptide as an indicator of long-term survival after acute myocardial infarction: comparison with plasma midregional pro-atrial natriuretic peptide: the LAMP (Leicester Acute Myocardial Infarction Peptide) study.  J Am Coll Cardiol. 2008;51 :1857-64

Khan SQ, O’Brien RJ, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL.  Prognostic value of Mid-regional pro-Adrenomedullin in Patients With Acute Myocardial Infarction. Leicester Acute Myocardial Infarction Peptide (LAMP) Study. J Am Coll Cardiology 2007; 49 : 1525-32

Willingale R, Jones DJL, Lamb JH, Quinn PA, Farmer PB, Ng LL.   Searching for biomarkers of heart failure in the mass spectra of blood plasma. Proteomics 2006; 6:5903-14

Jones DJL, Willingale R, Quinn PA, Lamb JH, Farmer PB, Davies JE, Ng LL.   Improving the diagnostic accuracy of N-terminal B-type natriuretic peptide in human systolic heart failure by plasma profiling using mass spectrometry. J Proteome Research 2007; 6 : 3329-3334

Emberson JR, Ng LL, Armitage J, Bowman L, Parish S, Collins R.  N-terminal pro-B-type natriuretic peptide, vascular disease risk and cholesterol reduction among 20 536 patients in the MRC/BHF Heart Protection Study.  J Am College Cardiology 2007; 49 : 311-319

Khan SQ, O’Brien RJ, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL.  C-terminal proVasopressin (Copeptin) as a Novel and Prognostic Marker In Acute Myocardial Infarction- Leicester Acute Myocardial Infarction Peptide  (LAMP) Study. Circulation 2007; 115 : 2103-2110

Ng LL, Loke I, Davies JE, Geeranavar S, Khunti K, Stone M, Chin DT, Squire IB.  Community screening for heart failure using plasma and urinary natriuretic peptides. Journal of American College of Cardiology 2005 ; 45 : 1043-50

Ng LL, Loke I, O’Brien RJ, Squire IB, Davies JE.  Plasma Urotensin in Human Systolic Heart Failure. Circulation  2002; 106: 2877-2880

Omland T, Persson A, Ng LL, O’Brien R, Karlsson T, Herlitz J, Hartford M, Caidahl K.  N-terminal Pro-B-type Natriuretic Peptide and Long-Term Mortality in Acute Coronary Syndromes. Circulation 2002; 106 : 2913-2918

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