Professor Gavin J Murphy

Professor Gavin Murphy British Heart Foundation Professor of Cardiac Surgery, University of Leicester / Honorary Consultant Cardiac Surgeon, University Hospitals of Leicester NHS Trust 

BSc in Physiology, Bristol, 1991
MBChB, Bristol, 1994
FRCS (Eng), 1998
MD, Leicester, 2003
FRCS (C.Th), 2005

Tel: 0116 258 3054

Email: gjm19@le.ac.uk  

Address: Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP

For general enquiries please email: Sue Page Tel: 0116 258 3021.

Research Interests

  • Inflammatory Organ Injury Post Cardiac Surgery
  • Blood Management

Professor Gavin Murphy's Research Group  and Newsletter

Current Committee Memberships

Chairman, Academic and Research Committee, Society for Cardiothoracic Surgery in UK and Ireland (SCTS) 2015-
Member SCTS Executive 2015-
Member Academic and Research Committee British Cardiac Society 2013-
Associate Editor Heart 2013-
Associate Editor Cochrane Heart Group 2014-
Member Academic and Research Committee, British Cardiac Society 2013-
NHS Blood and Transplant Systematic Review Initiative's Steering Group 2011-

Key Publications

Reeves BC, Pike K, Rogers CA, Brierley RCM, Stokes EA, Wordsworth S, Nash RL, Miles A, Mumford AD, Cohen A, Angelini GD, Murphy GJ for the TITRe2 investigators. A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery (TITRe2) HTA Journal June 2016.

Patel NN, Avlonitis V, Jones H, Sterne JAC, Reeves BC, Murphy GJ. Indications for red cell transfusion in cardiac surgery: A systematic review and meta-analysis of randomised controlled trials and observational studies. Lancet Haematol. 2015 Dec;2(12):e543-53.

Murphy GJ, Pike K, Rogers CA, Wordsworth S, Stokes EA, Angelini GD, Reeves BC on behalf of TITRe2 Investigators. Liberal or restrictive transfusion after cardiac surgery: TITRe2 randomized trial. New England Journal of Medicine 2015 Mar 12;372(11):997-1008.

Birnie K, Verheyden V, Pagano D, Bhabra B, Tilling K, Sterne JAS, Murphy GJ. Predictive models for Kidney Disease: Improving Global Outcomes (KDIGO) Defined Acute Kidney Injury in UK Cardiac Surgery. Critical Care 2014;18:606

Rogers CA, Pike K, Angelini GD, Reeves BC, Glauber M, Ferrarini M, Murphy GJ. An open randomized controlled trial of median sternotomy versus anterolateral left thoracotomy on morbidity and health care resource use in patients having off-pump coronary artery bypass surgery: the Sternotomy Versus Thoracotomy (STET) trial. J Thorac Cardiovasc Surg. 2013 Aug;146(2):306-16.e1-9.

Patel NN, Lin H, Jones C, Walkden G, Ray P, Sleeman PA, Angelini GD, Murphy GJ. Interactions of cardiopulmonary bypass and erythrocyte transfusion in the pathogenesis of pulmonary dysfunction in Swine. Anesthesiology. 2013 Aug;119(2):365-78

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, Murphy GJ. Reversal of anaemia with allogenic RBC transfusion prevents post cardiopulmonary bypass acute kidney injury in swine. Am J Physiol Renal Physiol 2011;301(3):F605-14.

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, Murphy GJ. Phosphodiesterase Type 5 inhibition prevents post cardiopulmonary bypass acute kidney injury in swine. Annals of Thoracic Surgery 2011;92(6):2168-76.

Patel NN, Rogers CS, Angelini GD, Murphy GJ. Pharmacological therapies for the prevention of acute kidney injury following cardiac surgery: A systematic review. Heart Failure Reviews 2011;16(6):553-67.

Patel NN, Toth T, Jones C, Lin H, Ray P, Sleeman P, Welsh G, Angelini GD, George SJ, Murphy GJ. Prevention of post cardiopulmonary bypass acute kidney injury by endothelin-A receptor blockade. Critical Care Medicine 2011;39:793-802.

Murphy GJ, Reeves BC, Rogers CA, Rizvi SIA, Culliford L, Angelini GD. Increased mortality, post-operative morbidity and cost following red blood cell transfusion in patients having cardiac surgery. Circulation 2007;116:2544-52.  

Links

Recent Publications

Professor Gavin Murphy's Research Group

Newsletter

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