Professor David G Lambert
Professor of Anaesthetic Pharmacology
BSc (First class honours) in Biological Sciences, University of Aston in Birmingham, 1984
PhD “Insulin release from cultured beta-cells”, University of Aston in Birmingham, 1987
Tel: 0116 258 5694
Email: dgl3@le.ac.uk
Address: Department of Cardiovascular Sciences, Clinical Division of Anaesthesia Critical Care & Pain Management,
University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, LE1 5WW
Research Interests
Nociceptin receptors
In collaboration with Dr G Calo and Prof Rowbotham
SAR-N/OFQ.
NOP desensitisation, recombinant and native. Transduction and genomic studies.
Cardiovascular effects of N/OFQ (collaborative with Dr Z Brookes, Sheffield)
Species differences in NOP/N/OFQ.
Measurement of N/OFQ in biological fluids.
Classical Opioid receptors
In collaboration with Dr G Calo, Prof Rowbotham and Dr JP Thompson
Basic pharmacology and comparison of recombinant MOP/DOP/KOP.
Measuring opioid receptors on lymphocytes and clinical utility.
Vanilloid (VR1) receptors
In collaboration with GSK and Dr A Hainsworth of DMU
Basic pharmacology.
Desensitisation (comparison with GPCR).
Comparison of anandamide action at VR1 and CB receptors.
Capsaicin and apoptosis.
Urotensin II
In collaboration with Dr G Calo, Prof LL Ng, Dr J Thompson, Prof Rowbotham and GSK
Evaluation of the urotensin II/UT receptor system.
SAR of the peptide and its actions in recombinant and native systems.
UT desensitization.
Measurement of urotensin II in plasma and CSF in normotensive and hypertensive populations.
External Positions and Distinctions
Member of Grant Awards Committee of BJA/RCoA., 2000
Visiting Professor to The University of Hirosaki, Japan, 1998, 2001-present
The Humphry Davy Medal awarded by The Royal College of Anaesthetists, 2002
Chair BJA/RCoA grants committee, 2002.
Edmund Riding Professor of The Royal College of Anaesthetists, 2003
Grants Officer for BJA/RCoA, 2003.
Visiting Professor to The University of Kyushu, Japan, 2004.
Associate Editor for The British Journal of Anaesthesia
Member Academic and Research Committee of RCoA
Member of the Anaesthetic Research Society, 1994-2004
Member of The European Society of Anaesthesiologists Pharmacology Sub-Committee
Member of the British Pharmacological Society and the European Opioid Colloquim
Consultant for Pfizer Veterinary Medicine, 2003-2004
Pharmacology Specialty Editor for Anaesthesia & Intensive Care Medicine, 2005
Links
Recent Reviews and Book Chapters
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