Dr Karl E Herbert
Senior Lecturer
BSc (Hons) Applied Biochemistry, First Class, 1982, Brunel University
PhD, 1986, The Medical College of St. Bartholomew's Hospital, University of London
Email: keh3@le.ac.uk
Address: Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP
Research Interests
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Molecular and cellular mechanisms of cardiovascular ageing
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Oxidative DNA damage and repair in humans
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Mitochondria and cellular oxidative stress
Key Publications
Wilson WR, Herbert KE, Mistry Y, Stevens SE, Patel HR, Hastings RA, Thompson MM, Williams B. Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease. Eur Heart J. 2008 Nov 29 21 2689-94
Herbert KE, Mistry Y, Hastings R, Poolman T, Niklason L, Williams B. Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways. Circ Res. 2008 Feb 1 102 2 201-8
Herbert KE, Fletcher S, Chauhan D, Ladapo A, Nirwan J, Munson S, Mistry P. Dietary supplementation with different vitamin C doses: no effect on oxidative DNA damage in healthy people. Eur J Nutr. 2006 Mar 45 2 97-104
Hastings R, Li NC, Lacy PS, Patel H, Herbert KE, Stanley AG, Williams B. Rapid telomere attrition in cardiac tissue of the ageing Wistar rat. Exp Gerontol. 2004 May 39 5 855-7
Cooke MS, Podmore ID, Mistry N, Evans MD, Herbert KE, Griffiths HR, Lunec J. Immunochemical detection of UV-induced DNA damage and repair. J Immunol Methods. 2003 Sep 280 1-2 125-33
Mistry P, Herbert KE. Modulation of hOGG1 DNA repair enzyme in human cultured cells in response to pro-oxidant and antioxidant challenge. Free Radic Biol Med. 2003 Aug 15 35 4 397-405
Cooke MS, Mistry N, Ahmad J, Waller H, Langford L, Bevan RJ, Evans MD, Jones GD, Herbert KE, Griffiths HR, Lunec J. Deoxycytidine glyoxal: lesion induction and evidence of repair following vitamin C supplementation in vivo. Free Radic Biol Med. 2003 Jan 15 34 2 218-25
Ravanat JL, Douki T, Duez P, Gremaud E, Herbert K, Hofer T, Lasserre L, Saint-Pierre C, Favier A, Cadet J. Cellular background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up. Carcinogenesis. 2002 Nov 23 11 1911-8
Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P and Lunec J Vitamin C exhibits pro-oxidant properties Nature 1998 392 559
Membership of Learned Societies
Society for Free Radical Biology and Medicine
