Professor of Thrombosis & Haemostasis
Cardiovascular Theme Lead

BSc (Biology), 1971, University of London
PhD (Biochemistry), 1979, University of London

Tel: 0116 258 3026

Email: ahg5@le.ac.uk

Address: Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP

For general enquiries, please email the secretary, Louise Goddard, or telephone 0116 258 3045

Research Interests

• Haemostatic regulation in atherothrombotic diseases

• Platelet biology

• Functional genomics of platelets and haemostasis

• Genetics of cardiovascular disease

• Platelet transfusion

External Positions

Current:
Principal Editor: Platelets 2009-

Past:
Member of the NIHR Doctoral Training Fellowship Panel 2005-2010
Reviews Editor: Platelets 2005-2009
Committee Member: British Atherosclerosis Society 2001-2004
President: British Society for Haemostasis & Thrombosis 2001-2003
Editor-in-Chief: Clinical Science  2001-2003
Editorial Board of Clinical Science, 1995-2001 (Associate Editor for Cardiovascular Section, 2002-2006)
Committee Member; British Society for Haemostasis & Thrombosis 1996-2001

Commercial Links

Founding Director of a University Spin-out company, Haemostatix Ltd, developing novel first-in-class clotting agents for the treatment of bleeding.

Membership of Learned Societies

International Society on Thrombosis & Haemostasis, 1999-
British Society for Haematology, 1997-
British Atherosclerosis Society, 1994-
British Society for Haemostasis & Thrombosis, 1982-
Association of Clinical Biochemists 1997-2001
British Society for Immunology 1979-1995
British Society for Cell Biology 1976-1986
Biochemical Society 1975-1986

Key Publications

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM. BCL2/BCL-XL-inhibition induces apoptosis, disrupts cellular calcium homeostasis and prevents platelet activation. Blood. 2011 May 11 Epub

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I; Cardiogenics, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Münzel T, Musunuru K, Nahrstaedt J, Nelson CP, Nöthen MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WH, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JC, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, März W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J; CARDIoGRAM Consortium, Samani NJ. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011 Mar 6 43 4 333-8

Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray EE, Cyster JG; Cardiogenics Consortium, Erdmann J, Hengstenberg C, Maouche S, Ouwehand WH, Rice CM, Samani NJ, Schunkert H, Goodall AH, Schulz H, Roider HG, Vingron M, Blankenberg S, Münzel T, Zeller T, Szymczak S, Ziegler A, Tiret L, Smyth DJ, Pravenec M, Aitman TJ, Cambien F, Clayton D, Todd JA, Hubner N, Cook SA. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature. 2010 Sep 23 467 7314 460-4

Goodall AH, Burns P, Salles I, Macaulay IC, Jones CI, Ardissino D, de Bono B, Bray SL, Deckmyn H, Dudbridge F, Fitzgerald DJ, Garner SF, Gusnanto A, Koch K, Langford C, O'Connor MN, Rice CM, Stemple D, Stephens J, Trip MD, Zwaginga J-J, Samani NJ, Watkins NA, Maguire PB, Ouwehand WH, on behalf of the Bloodomics Consortium. Transcription Profiling in Human Platelets Reveals LRRFIP1 as a Novel Protein Regulating Platelet Function. Blood 2010 Nov 25;116(22):4646-4656

Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, Menzel S, Altshuler D, Bradley JR, Bumpstead S, Burnett MS, Devaney J, Döring A, Elosua R, Epstein SE, Erber W, Falchi M, Garner SF, Ghori MJ, Goodall AH, William R, Hakonarson HH, Hall AS, Hammond N, Hengstenberg C, Illig T, König IR, Knouff CW, McPherson R, Melander O, Mooser V, Nauck M, Nieminen MS, O'Donnell CJ, Peltonen L, Potter SC, Prokisch H, Rader DJ, Rice CM, Roberts R, Salomaa V, Sambrook J, Schreiber S, Schunkert H, Schwartz SM, Serbanovic-Canic J, Sinisalo J, Siscovick DS, Stark K, Surakka I, Stephens J, Thompson JR, Völker U, Völzke H, Watkins NA, Wells GA, Wichmann HE, Van Heel DA, Tyler-Smith C, Thein SL, Kathiresan S, Perola M, Reilly MP, Stewart AF, Erdmann J, Samani NJ, Meisinger C, Greinacher A, Deloukas P, Ouwehand WH, Gieger C. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet. 2009 Nov;41(11):1182-90 

Jones CI, Bray S, Garner SF, Stephens J, de Bono B, Angenent WGJ, Bentley D, Burns P, Coffey A, Deloukas P, Earlthrow M, Farndale RF, Hoylaerts MF, Koch K, Rankin A, Rice CM, Rogers J, Samani NJ, Steward M, Walker A, Watkins NA, Akkerman J-W, Dudbridge F, Goodall AH, Ouwehand WH, on behalf of the Bloodomics consortium. A functional genomics approach reveals novel quantitative trait loci associated with platelet signalling pathways. Blood 2009 Aug 13;114(7):1405-16. [Epub 2009 May 8].

Soranzo N, Rendon A, Gieger C, Jones CI, Watkins NA, Menzel S, Doring A, Stephens J, Prokisch H, Erber W, Potter SC, Bray SL, Burns P, Jolley J, Falchi M, Kuhnel B, Erdmann J, Schunkert H, Samani N, Illig T, Garner SF, Rankin A, Meisinger C, Bradley JR, Thein SL, Goodall AH, Spector TD, Deloukas P, Ouwehand WH. A novel variant on chromosome 7Q22.3 associated with mean platelet volume, counts and function. Blood. 2009 Apr 16 113 16 3831-7

O’Connor MN, Salles II, Cvejic A, Watkins NA, Walker A, Garner SF, Jones  CI, Macaulay IC, Steward M, Zwaginga J-J, Bray SL, Dudbridge F, de Bono B, Goodall AH, Deckmyn H, Stemple DL, Ouwehand WH on behalf of the Bloodomics Consortium. Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood 2009 May; 113(19): 4754-4762.

Payne DA, Jones CI, Hayes PD, Naylor AR, Goodall AH. Therapeutic Benefit of Low-Dose Clopidogrel in Patients Undergoing Carotid Surgery Is Linked to Variability in the Platelet Adenosine Diphosphate Response and Patients' Weight. Stroke. 2007 (Sept); 38: 2464-2469

Jones CI, Garner SF Angenent W, Bernard A, Berzuini C, Burns P, FarndaleRW, Hogwood J, Rankin A, Stephens JC, Tom BD, Walton J, Dudbridge F, Ouwehand WH, Goodall AH: on behalf of the BLOODOMICS consortium. Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. Journal of Thrombosis & Haemostasis 2007 Aug; 5(8): 1756-65.

Links

Recent Papers

Cardiovascular Theme pages