Professor Timothy J Coats

Professor Tim CoatsProfessor of Emergency Medicine

BSc (Psychology) 1983, University of London
MB BS, 1986, University of London
FRCS (Eng), 1990
FFAEM 1996
MD, 1997, University of London

Tel: 0116 252 3263


Address: Department of Cardiovascular Sciences, University of Leicester, 
Level G, Jarvis Building RMO, Infirmary Square, Leicester, LE1 5WW

For general enquiries, please email the secretary, Elizabeth Cadman, or telephone 0116 258 5965

Research Interests

  • Diagnostics and monitoring in Emergency Care
  • Coagulation following injury
  • Predictive modeling of outcome following injury

External Positions

Chair FAEM Research Committee 2000-2009
Chair Trauma Audit and Research Network (TARN)
Chair NIHR Injuries and Emergencies National Specialist Group

Key Publications

Mouncey PR, Osborn TM, Power GS, Harrison DA, Sadique MZ, Grieve RD, Jahan R, Harvey SE, Bell D, Bion JF, Coats TJ, Singer M, Young JD, and Rowan KM, for the ProMISe Trial Investigators. (2015). Trial of early, goal-directed resuscitation for septic shock. N Engl J Med, 372(14), 1301-1311.

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Study Group. Inc Coats TJ. (2014) Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. June 4;311(21):2181-90

Goodacre S, Cohen J, Bradburn M, Gray A, Benger J, Coats T; 3Mg Research Team. Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomised controlled trial. Lancet Respir Med. 2013 Jun;1(4):293-300

Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt BJ, Lecky F, Brohi K, Willett K; CRASH-2 Collaborators. Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ. 2012 Sep 11;345:e5839

CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011 Mar 26 377 9771 1096-101

Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2011 Jan 19 1

Goodacre SW, Bradburn M, Cross E, Collinson P, Gray A, Hall AS; RATPAC Research Team. The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department. Heart. 2011 Feb 97 3 190-6

CRASH-2 trial collaborators, Shakur H, Roberts R, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S.
Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010 Jul 3;376(9734):23-32. Epub 2010 Jun 14

Shakur H, Roberts I, Barnetson L, Coats T. Clinical trials in emergency situationsBMJ. 2007 Jan 27 334 7586 165-6

Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathyJ Trauma. 2003 Jun 54 6 1127-30

Becalick DC, Coats TJ. Comparison of artificial intelligence techniques with UKTRISS for estimating probability of survival after trauma. UK Trauma and Injury Severity ScoreJ Trauma. 2001 Jul 51 1 123-33


Full list of papers for 2015-2006

Papers before 2006

Emergency Medicine

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