Clinical Lecturer

MBBS (Hons ) – University Of Sydney 1998
MRCS – Royal College of Surgeons of England 2002
PhD – St George’s, University of London 2009

Tel: 0116 252 3252

Email: ec172@le.ac.uk

Address: Department of Cardiovascular Sciences,
University of Leicester, Sir Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX

For general enquiries please email the secretary, Mrs Sandie Smith, or telephone 0116 252 3252

Research Interests

I was appointed as clinical lecturer in vascular surgery in June 2010. My research interest is abdominal aortic aneurysm (AAA) wall biology. My PhD project was undertaken in St George’s, University of London where I investigated the role of angiogenesis in AAA rupture. This work was supported by a research fellowship from the Royal College of Surgeons of England and grants from Peel Medical Research Council and Society of Academic  Research Surgery.

Key Publications

Choke E, Cockerill GW, Dawson J, Howe F, Wilson WR, Loftus IM, Thompson MM. Vascular endothelial growth factor enhances angiotensin II-induced aneurysm formation in apolipoprotein E-deficient mice. J Vasc Surg. 2010 May 13.

Choke E, Cockerill GW, Laing K, Dawson J, Wilson WR, Loftus IM, Thompson MM. Whole genome-expression profiling reveals a role for immune and inflammatory response in abdominal aortic aneurysm rupture. Eur J Vasc Endovasc Surg. 2009 Mar;37(3):305-10.

Dawson JA, Choke E, Cockerill GW, Loftus IM, Thompson MM. The long-term effects of open and endovascular aneurysm repair on circulating interleukin-6. Eur J Vasc Endovasc Surg. 2009 Jan;37(1):43-5.

Wilson WR, Anderton M, Choke EC, Dawson J, Loftus IM, Thompson MM. Elevated plasma MMP1 and MMP9 are associated with abdominal aortic aneurysm rupture. Eur J Vasc Endovasc Surg. 2008 May;35(5):580-4.

Dawson J, Cockerill GW, Choke E, Belli AM, Loftus I, Thompson MM. Aortic aneurysms secrete interleukin-6 into the circulation. J Vasc Surg. 2007 Feb;45(2):350-6.

Choke E, Cockerill GW, Dawson J, Wilson RW, Jones A, Loftus IM, Thompson MM. Increased angiogenesis at the site of abdominal aortic aneurysm rupture. Ann N Y Acad Sci. 2006 Nov;1085:315-9.

Choke E, Thompson MM, Jones A, Torsney E, Dawson J, Laing K, Nasr H, Loftus IM, Cockerill GW. Gene expression profile of abdominal aortic aneurysm rupture. Ann N Y Acad Sci. 2006 Nov;1085:311-4.

Choke E, Cockerill GW, Dawson J, Chung YL, Griffiths J, Wilson RW, Loftus IM, Thompson MM. Hypoxia at the site of abdominal aortic aneurysm rupture is not associated with increased lactate. Ann N Y Acad Sci. 2006 Nov;1085:306-10.

Choke E, Thompson MM, Dawson J, Wilson WR, Sayed S, Loftus IM, Cockerill GW. Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines. Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2077-82.

Choke E, Cockerill G, Wilson WR, Sayed S, Dawson J, Loftus I, Thompson MM. A review of biological factors implicated in abdominal aortic aneurysm rupture. Eur J Vasc Endovasc Surg. 2005 Sep;30(3):227-44.

Links

Recent Papers