![[The University of Leicester]](unilogo.gif)
Professor Nick Brindle
Professor of Cell Signalling
Bsc University of Leeds 1982
PhD University of Manchester 1985
Tel: 0116 252 5802
Email: npjb1@le.ac.uk
Address: Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX
For general enquiries, please email the secretary, Mrs Sandie Smith, or telephone 0116 252 3252
Research Interests
- Molecular mechanisms of signalling by receptor tyrosine kinases
Key Publications
Singh H, Milner CS, Aguilar Hernandez MM, Patel N, Brindle NP. Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases. Cell Signal. 2009 21 1346-50
Moss AJ, Sharma S, Brindle NP. Rational design and protein engineering of growth factors for regenerative medicine and tissue engineering. Biochem Soc Trans. 2009 37 717-21
Marron MB, Singh H, Tahir TA, Kavumkal J, Kim HZ, Koh GY, Brindle NP. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. J Biol Chem. 2007 282 30509-17
Tadros A, Hughes DP, Dunmore BJ, Brindle NP. ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. Blood. 2003 102 4407-9
Hughes DP, Marron MB, Brindle NP. The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. Circ Res. 2003 92 630-6
