Professor Matt Bown

portrait2Professor of Vascular Surgery

Department of Cardiovascular Sciences

University of Leicester
Robert Kilpatrick Clinical Sciences Building
Leicester Royal Infirmary
Leicester, LE2 7LX

Tel: +44 (0)116 252 3190
Email: m.bown@le.ac.uk

 

Personal details

  • MB BCh - University of Wales College of Medicine - 1997
  • MD - University of Leicester - 2003
  • FRCS - The Royal College of Surgeons of England - 2008
  • PGCert (Bioinformatics) - Oxford University - 2009

I was initially appointed as a Clinical Lecturer in 2003 and, following the award of my CCT and a HEFCE Clinical Senior Lecturer Fellowship, was appointed as a Senior Lecturer in 2010. In 2016, I was promoted to the position of Professor of Vascular Surgery.

  • Honorary Consultant Vascular Surgeon, University Hospitals of Leicester NHS Trust
  • Director of Clinical Academic Training, University of Leicester
  • Training Lead, NIHR Leicester Cardiovascular Biomedical Research Unit
  • Member of national Integrated Academic Training Advisory Committee
  • Member of the international advisory board, Heart
  • Member of the editorial board, Atherosclerosis
  • NICE Specialist Advisor for Vascular Surgery (Interventional Procedures Programme)
  • Member of Council, Society for Academic and Research Surgery (SARS)
  • NIHR Doctoral Research Fellowship panel member

Publications

Full list of papers for 2016-2006

Sidloff D, Stather P, Dattani N, Bown M, Thompson J, Sayers R, Choke E. Aneurysm global epidemiology study: public health measures can further reduce abdominal aortic aneurysm mortality.Circulation. 2014; 129(7): 747-53.

IMPROVE Trial Investigators, Powell JT, Sweeting MJ, Thompson MM, Ashleigh R, Bell R, Gomes M, Greenhalgh RM, Grieve R, Heatley F, Hinchliffe RJ, Thompson SG, Ulug P. Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes from IMPROVE randomised trial. BMJ. 2014; 348: f7661.

Bradley DT, [46 authors], Bown MJ. A variant in LDLR is associated with abdominal aortic aneurysm. Circ Cardiovasc Genet. 2013; 6(5): 498-504.

Thompson SG, Brown LC, Sweeting MJ, Bown MJ, Kim LG, Glover MJ, Buxton MJ, Powell JT. Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness. Health Technol Assess. 2013; 17(41): 1-118.

Jones GT, Bown MJ, Gretarsdottir S, Romaine SP, Helgadottir A, Yu G, et al. A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Hum Mol Genet. 2013; 22(14): 2941-7.

The RESCAN Collaborators (Authors: Bown MJ, Sweeting MJ, Brown LC, Powell JT, Thompson SG. Surveillance intervals for small abdominal aortic aneurysms: an individual patient data meta-analysis. J Am Med Assoc. 2013; 309(8): 806-813.

Harrison SC, Smith AJ, Jones GT, Swerdlow DI, Rampuri R, Bown MJ; on behalf of the Aneurysm Consortium, Folkersen L, Baas AF, de Borst GJ, Blankensteijn JD, Price JF, van der Graaf Y, McLachlan S, Agu O, Hofman A, Uitterlinden AG, Franco-Cereceda A, Ruigrok YM, Van't Hof FN, Powell JT, van Rij AM, Casas JP, Eriksson P, Holmes MV, Asselbergs FW, Hingorani AD, Humphries SE. Interleukin-6 receptor pathways in abdominal aortic aneurysm. Eur Heart J. 2013; 34(48): 3707-16.

Bloomer LD, Bown MJ, Tomaszewski M. Sexual dimorphism of abdominal aortic aneurysms: A striking example of "male disadvantage" in cardiovascular disease. Atherosclerosis. 2012; 225(1): 22-8.

Wild JB, Stather PW, Sylvius N, Choke E, Sayers RD, Bown MJ. Low density lipoprotein receptor related protein 1 and abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2012; 44(2): 127-32.

Ehsan S, Ball G, Choke E, Molyneux KM, London NJ, Herbert KE, Barratt J, Sayers RD, Bown MJ. Disease specific biomarkers of abdominal aortic aneurysms detected by surface enhanced laser desorption ionization time of flight mass spectrometry. Eur J Vasc Endovasc Surg. 2012; 44(1): 52-4.

Sweeting MJ, Thompson SG, Brown LC, Powell JT; RESCAN collaborators. Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms. Br J Surg. 2012; 99(5): 655-65.

Choke E, Vijaynagar B, Thompson J, Nasim A, Bown MJ, Sayers RD. Changing epidemiology of abdominal aortic aneurysms in England and Wales: older and more benign? Circulation. 2012; 125(13): 1617-25.

Bown MJ, Jones GT, Harrison SC, (51 authors), Sayers RD, Deloukas P, Samani NJ. Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.  Am J Hum Genet. 2011; 89(5): 619-27.

Salem MK, Sayers RD, Bown MJ, Naylor AR. Response to comment on "Rapid Access Carotid Endarterectomy can be Performed in the Hyperacute Period without a Significant Increase in Procedural Risks" Eur J Vasc Endovasc Surg. 2011; 42(3): 403-4.

Tambyraja AL, Fishwick NG, Bown MJ, Nasim A, McCarthy MJ, Sayers RD. Fenestrated Aortic Endografts for Juxtarenal Aortic Aneurysm: Medium Term Outcomes. Eur J Vasc Endovasc Surg. 2011; 42(1): 54-8.

Naylor AR, Bown MJ. Stroke after Cardiac Surgery and its Association with Asymptomatic Carotid Disease: An Updated Systematic Review and Meta-analysis. Eur J Vasc Endovasc Surg. 2011; 41(5): 607-24.

Bradley DT, Badger SA, Bown MJ, Sayers RD, Hughes AE. Coding polymorphisms in the genes of the alternative complement pathway and abdominal aortic aneurysm. Int J Immunogenet. 2011; 38(3): 243-8.

Salem MK, Butt HZ, Watts AP, Sayers RD, Bown MJ, Naylor AR. Spontaneous Cerebral Embolisation in Asymptomatic and Recently Symptomatic Patients with TIA/Minor Stroke. Eur J Vasc Endovasc Surg. 2011; 41(6): 720-5.

Salem MK, Sayers RD, Bown MJ, Eveson DJ, Robinson TG, Naylor AR. Rapid Access Carotid Endarterectomy can be Performed in the Hyperacute Period without a Significant Increase in Procedural Risks. Eur J Vasc Endovasc Surg. 2011; 41(2): 222-8.

Malkawi AH, Resch TA, Bown MJ, Manning BJ, Poloniecki JD, Nordon IM, Loftus IM, Thompson MM, Hinchliffe RJ. Sizing Fenestrated Aortic Stent-grafts. Eur J Vasc Endovasc Surg. 2011; 41(3): 311-6.

Bown MJ, Sutton AJ. Quality Control in Systematic Reviews and Meta-analyses. Eur J Vasc Endovasc Surg. 2010; 40(5): 669-77.

Obukofe B, Sayers RD, Thompson J, Sandford RM, London NJ, Samani NJ, Bown MJ. Is There an Association between Angiotensin Converting Enzyme (ACE) Genotypes and Abdominal Aortic Aneurysm? Eur J Vasc Endovasc Surg. 2010; 40(4): 457-60.

Stephenson JA, Gravante G, Butler NA, Sorge R, Sayers RD, Bown MJ. The Systemic Inflammatory Response Syndrome (SIRS)-Number and Type of Positive Criteria Predict Interventions and Outcomes in Acute Surgical Admissions. World J Surg. 2010; 34(11): 2757-64.

Sandford RM, Batchelder AJ, Bown MJ, Sayers RD. Pre-discharge duplex ultrasound scans detect endoleaks not seen on completion angiography after endovascular aneurysm repair. J Endovasc Ther. 2010; 17(3): 349-53.

Butt HZ, Atturu G, London NJ, Sayers RD, Bown MJ. Telomere length dynamics in vascular disease: a review. Eur J Vasc Endovasc Surg. 2010; 40(1): 17-26.

Gibbs DM, Bown MJ, Hussey G, Naylor AR. The Ectatic Aorta: No Benefit in Surveillance. Ann Vasc Surg. 2010; 24(7): 908-11.

Atturu G, Brouilette S, Samani NJ, London NJ, Sayers RD, Bown MJ. Short Leukocyte Telomere Length is Associated with Abdominal Aortic Aneurysm (AAA). Eur J Vasc Endovasc Surg. 2010; 39(5): 559-64.

Rayt HS, Sandford RM, Salem M, Bown MJ, London NJ, Sayers RD. Conservative Management of Type 2 Endoleaks is not Associated with Increased Risk of Aneurysm Rupture. Eur J Vasc Endovasc Surg. 2009; 38(6): 718-23.

Oshin OA, Bown MJ, McWilliams RG, Brennan JA, Vallabhaneni SR. Optimal technique for imaging iliac segments during endovascular repair of abdominal aortic aneurysms. J Endovasc Ther. 2009; 16(3): 373-9.

Bown MJ, Bolia A, Sutton AJ. Subintimal Angioplasty: Meta-analytical Evidence of Clinical Utility. Eur J Vasc Endovasc Surg. 2009; 38(3): 323-37.

Sandford B, Bown M, London N, Sayers R. The role of the CCR5 Delta32 polymorphism in abdominal aortic aneurysms. Int J Immunogenet. 2009; 36(4): 199-205.

Sharpe RY, Walker J, Bown MJ, Naylor MB, Evans DH, Naylor AR. Identifying the High-risk Patient with Clinically Relevant Embolisation After Carotid Endarterectomy. Eur J Vasc Endovasc Surg. 2009; 37(1): 1-7.

Middleton RK, Bown MJ, Lloyd GM, Jones JL, London NJ, Sayers RD. Characterisation of Interleukin-8 and Monocyte Chemoattractant Protein-1 Expression within the Abdominal Aortic Aneurysm and their Association with Mural Inflammation. Eur J Vasc Endovasc Surg. 2009; 37(1): 46-55.

Rayt HS, Sutton AJ, London NJ, Sayers RD, Bown MJ. A Systematic Review and Meta-analysis of Endovascular Repair (EVAR) for Ruptured Abdominal Aortic Aneurysm. Eur J Vasc Endovasc Surg. 2008; 36(5): 536-44.

Aneurysm Consortium. Bown MJ, Child AH, Cockerill G, Deloukas P, Golledge J, Hafez H, Humphries SE, Jones GT, Norman PE, Powell JT, van Rij AM, Sayers RD, Samani NJ, Scott DJ, Thompson JR, Thompson MM. Genome Wide Association Studies: identifying the genes that determine the risk of abdominal aortic aneurysm. Eur J Vasc Endovasc Surg. 2008; 36(4): 395-6.

Sandford RM, Bown MJ, Sayers RD, Fishwick G, London NJ, Nasim A. Endovascular abdominal aortic aneurysm repair: 5-year follow-up results. Ann Vasc Surg. 2008; 22(3): 372-8.

Rayt H, Lambert K, Bown M, Fishwick G, Morgan R, McCarthy M, London N, Sayers R. Can Surgeons Assess CT Suitability for Endovascular Repair (EVAR) in Ruptured Abdominal Aortic Aneurysm? Implications for a Ruptured EVAR Trial. Cardiovasc Intervent Radiol. 2008; 31(5): 865-9.

Rayt HS, Bown MJ, Lambert KV, Fishwick NG, McCarthy MJ, London NJ, Sayers RD. Buttock Claudication and Erectile Dysfunction After Internal Iliac Artery Embolization in Patients Prior to Endovascular Aortic Aneurysm Repair. Cardiovasc Intervent Radiol. 2008; 31(4): 728-34.

Bown MJ, Braund PS, Thompson JR, London NJL, Samani NJ, Sayers RD. Association Between the Coronary Artery Disease Risk Locus on Chromosome 9p21.3 and Abdominal Aortic Aneurysm Circ Cardiovasc Genet. 2008; 1(1): 39-42.

Bown MJ, Lloyd GM, Sandford RM, Thompson JR, London NJ, Samani NJ, Sayers RD. The interleukin-10-1082 'A' allele and abdominal aortic aneurysms. J Vasc Surg. 2007; 46(4): 687-93.

Sandford RM, Bown MJ, Sayers RD, London JN, Naylor AR, McCarthy MJ. Is infrainguinal bypass grafting successful following failed angioplasty? Eur J Vasc Endovasc Surg. 2007; 34(1): 29-34.

Sandford RM, Bown MJ, Sayers RD. Scoring systems do not accurately predict outcome following abdominal aortic aneurysm repair. ANZ J Surg. 2007; 77(4): 275-82.

Middleton RK, Lloyd GM, Bown MJ, Cooper NJ, London NJ, Sayers RD. The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: a protein array study. J Vasc Surg. 2007; 45(3): 574-80.

Franks SC, Sutton AJ, Bown MJ, Sayers RD. Systematic review and meta-analysis of 12 years of endovascular abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 2007; 33(2): 154-71.

Sandford RM, Bown MJ, Fishwick G, Murphy F, Naylor M, Sensier Y, Sharpe R, Walker J, Hartshorn T, London NJ, Sayers RD. Duplex ultrasound scanning is reliable in the detection of endoleak following endovascular aneurysm repair. Eur J Vasc Endovasc Surg. 2006; 32(5): 537-41.

Papers before 2006

Bown MJ, Weston S, Horsburgh T, Nicholson ML, Bell PR, Sayers RD. A comparison of methods for determining genotypes at the tumour necrosis factor-alpha-308, interleukin (IL)-1beta+3953, IL-6 -174 and IL-10 -1082/-819/-592 polymorphic loci. Int J Immunogenet. 2005; 32(2): 83-90.

Norwood MG, Horsburgh T, Bown MJ, Sayers RD. Neutrophil activation occurs in the lower-limbs of patients undergoing elective repair of abdominal aortic aneurysm. Eur J Vasc Endovasc Surg. 2005; 29(4): 390-4.

Lloyd GM, Newton JD, Norwood MG, Franks SC, Bown MJ, Sayers RD. Patients with abdominal aortic aneurysm: are we missing the opportunity for cardiovascular risk reduction? J Vasc Surg. 2004; 40(4): 691-7.

Bown MJ, Norwood MG, Loftus IM, Spiers P, Sayers RD. The Surgical Acute Care Unit (SACU): effects on surgical workload and mortality. ANZ J Surg. 2004; 74(10): 881-4.

Norwood MG, Bown MJ, Sutton AJ, Nicholson ML, Sayers RD. Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legs. Br J Surg. 2004; 91(9): 1153-6.

Norwood MG, Bown MJ, Furness PN, Berry DP. Actinomycosis of the sigmoid colon: an unusual cause of large bowel perforation. ANZ J Surg. 2004; 74(9): 816-8.

Bown MJ, Horsburgh T, Nicholson ML, Bell PR, Sayers RD. Cytokines, their genetic polymorphisms, and outcome after abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 2004; 28(3): 274-80.

Norwood MG, Bown MJ, Bell PR, Spiers P, Leslie A, Sayers RD. Evaluation of level 1 care facilities for vascular patients. ANZ J Surg. 2004; 74(5): 346-9.

Lloyd GM, Bown MJ, Norwood MG, Deb R, Fishwick G, Bell PR, Sayers RD. Feasibility of preoperative computer tomography in patients with ruptured abdominal aortic aneurysm: a time-to-death study in patients without operation. J Vasc Surg. 2004; 39(4): 788-91.

Norwood MG, Bown MJ, Lloyd G, Bell PR, Sayers RD. The clinical value of the systemic inflammatory response syndrome (SIRS) in abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 2004; 27(3): 292-8.

Norwood MG, Polimenovi NM, Sutton AJ, Bown MJ, Sayers RD. Abdominal aortic aneurysm repair in patients with chronic renal disease. Eur J Vasc Endovasc Surg. 2004; 27(3): 287-91.

Bown MJ, Cooper NJ, Sutton AJ, Prytherch D, Nicholson ML, Bell PR, Sayers RD. The post-operative mortality of ruptured abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 2004; 27(1): 65-74.

Research

We are looking for men with abdominal aortic aneurysms (AAA) to join our UK Aneurysm Growth Study research programme. More information can be found on the project page here.

Interests

During my time with the department, I have been involved in a continuing research programme investigating the pathogenesis and management of abdominal aortic aneurysms (AAA). My laboratory research mainly involves genomic studies of AAA and to date we have identified key novel associations between AAA and the LRP1, LDLR and SORT1 genes. My clinical research is focused on the management of early-stage aneurysmal disease including screening.

With previous funding from the Circulation Foundation, and now the British Heart Foundation, I have set up the UK Aneurysm Growth Study, a large prospective cohort study of men with small AAA. This resource will be used to identify clinical and biological factors associated with the growth of AAA and bring together my previous laboratory research with my current clinical research.

I provided clinical input for the NIHR HTA project, 'RESCAN'. Through the analysis of over 15,000 individual AAA patient datasets we were able to identify that lengthening the intervals between AAA surveillance scans was feasible whilst remaining clinically effective at preventing AAA rupture. These new surveillance intervals are currently under consideration by the NHS AAA Screening Programme and the primary results of this project were published in JAMA (2013).

I am currently working with colleagues from Cambridge, Brunel and Imperial College on an NIHR HTA funded project 'Screening Women for Abdominal Aortic Aneurysms (SWAN)' to construct an economic model for AAA screening in women. In 2016 I obtained funding from the NIHR to conduct a pilot study of AAA screening in women, the 'Female Aneurysm screening STudy (FAST)'. Together, these two projects will help the NHS decide whether to screen women for AAAs.

Funding sources

The Wellcome Trust

The Dunhill Medical Trust

The Circulation Foundation

The British Heart Foundation

NIHR

Training

Academic Vascular Surgery Training

Opportunities for training in academic vascular surgery in Leicester (ACF, ACL, Research Fellows, Lecturers)

In Leicester we have a strong track record in training academic vascular surgeons. We have an active cohort of junior surgeons pursuing post-graduate studies (MD or PhD) and regularly support Academic Clinical Fellows (ACF) and Academic Clinical Lecturers (ACL). Anyone interested in exploring these opportunities should contact Professor Matt Bown in the first instance.

Share this page: