Senior Lecturer in Vascular Surgery
MB BCh - University of Wales College of Medicine - 1997
MD - University of Leicester - 2003
FRCS - The Royal College of Surgeons of England - 2008
PGCert (Bioinformatics) - Oxford University - 2009
Telephone: 0116 252 3190 Email: email@example.com
Address: Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX
I was initially appointed as a Clinical Lecturer in 2003 and, following the award of my CCT and a HEFCE Clinical Senior Lecturer Fellowship, was appointed as a Senior Lecturer in 2010.
Honorary Consultant Vascular Surgeon, University Hospitals of Leicester NHS Trust
Director of Clinical Academic Training, University of Leicester
Training Lead, NIHR Leicester Cardiovascular Biomedical Research Unit
Member of national Integrated Academic Training Advisory Committee
Member of the international advisory board, Heart
Member of the editorial board, Atherosclerosis
NICE Specialist Advisor for Vascular Surgery (Interventional Procedures Programme)
Member of Council, Society for Academic and Research Surgery (SARS)
NIHR Doctoral Research Fellowship panel member
During my time with the department I have been involved in a continuing research programme investigating the pathogenesis of abdominal aortic aneurysms (AAA). My laboratory research mainly involves genomic studies of AAA and to date we have identified key novel associations between AAA and the LRP1, LDLR and SORT1 genes. My clinical research is focussed on the management of early-stage aneurysmal disease including screening.
With previous funding from the Circulation Foundation, and now the British Heart Foundation, I have set up the UK Aneurysm Growth Study, a large prospective cohort study of men with small AAA. This resource will be used to identify clinical and biological factors associated with the growth of AAA and bring together my previous laboratory research with my current clinical research.
I provided clinical input for the NIHR HTA project, “RESCAN”. Through the analysis of over 15,000 individual AAA patient datasets we were able to identify that lengthening the intervals between AAA surveillance scans was feasible whilst remaining clinically effective at preventing AAA rupture. These new surveillance intervals are currently under consideration by the NHS AAA Screening Programme and the primary results of this project were published in JAMA (2013).
I am currently working with colleagues from Cambridge, Brunel and Imperial College on an NIHR HTA funded project "Screening Women for Abdominal Aortic Aneurysms" to construct an economic model for AAA screening in women. In 2016 I obtained funding from the NIHR to conduct a pilot study of AAA screening in women. Together these two projects will help the NHS decide whether to screen women for AAAs.
RESCAN Collaborators, Bown MJ, Sweeting MJ, Brown LC, Powell JT, Thompson SG. Surveillance intervals for small abdominal aortic aneurysms: a meta-analysis. JAMA 2013 Feb 27;309(8):806-13.
Stather PW, Sylvius N, Wild JB, Choke E, Sayers RD, Bown MJ. Differential MicroRNA Expression Profiles in Peripheral Arterial Disease. Circ Cardiovasc Genet. 2013 Aug 26
Bradley DT, [46 authors], Bown MJ. A variant in LDLR is associated with abdominal aortic aneurysm. Circ Cardiovasc Genet. 2013 Oct;6(5):498-504.
Thompson SG, Brown LC, Sweeting MJ, Bown MJ, Kim LG, Glover MJ, Buxton MJ, Powell JT. Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness. Health Technol Assess. 2013 Sep;17(41):1-118
Jones GT, Bown MJ, Gretarsdottir S, Romaine SP, Helgadottir A, Yu G, et al. A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Hum Mol Genet. 2013 Jul 15;22(14):2941-7.
Harrison SC, Smith AJ, Jones GT, Swerdlow DI, Rampuri R, Bown MJ; on behalf of the Aneurysm Consortium, Folkersen L, Baas AF, de Borst GJ, Blankensteijn JD, Price JF, van der Graaf Y, McLachlan S, Agu O, Hofman A, Uitterlinden AG, Franco-Cereceda A, Ruigrok YM, Van't Hof FN, Powell JT, van Rij AM, Casas JP, Eriksson P, Holmes MV, Asselbergs FW, Hingorani AD, Humphries SE. Interleukin-6 receptor pathways in abdominal aortic aneurysm. Eur Heart J. 2013;34(48):3707-16
Bloomer LD, Bown MJ, Tomaszewski M. Sexual dimorphism of abdominal aortic aneurysms: A striking example of "male disadvantage" in cardiovascular disease. Atherosclerosis. 2012 Jul 9.
Wild JB, Stather PW, Sylvius N, Choke E, Sayers RD, Bown MJ. Low density lipoprotein receptor related protein 1 and abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2012 Aug;44(2):127-32.
Ehsan S, Ball G, Choke E, Molyneux KM, London NJ, Herbert KE, Barratt J, Sayers RD, Bown MJ. Disease specific biomarkers of abdominal aortic aneurysms detected by surface enhanced laser desorption ionization time of flight mass spectrometry. Eur J Vasc Endovasc Surg. 2012 Jul;44(1):52-4.
Sweeting MJ, Thompson SG, Brown LC, Powell JT; RESCAN collaborators. Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms. Br J Surg. 2012 May;99(5):655-65.
Choke E, Vijaynagar B, Thompson J, Nasim A, Bown MJ, Sayers RD. Changing epidemiology of abdominal aortic aneurysms in England and Wales: older and more benign? Circulation. 2012 Apr 3;125(13):1617-25.
Bown MJ, Jones GT, Harrison SC, (51 authors), Sayers RD, Deloukas P, Samani NJ. Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. Am J Hum Genet. 2011 Nov 11;89(5):619-27.
Bradley DT, Badger SA, Bown MJ, Sayers RD, Hughes AE. Coding polymorphisms in the genes of the alternative complement pathway and abdominal aortic aneurysm. Int J Immunogenet. 2011 Jun 38 3 243-8
Salem MK, Sayers RD, Bown MJ, Naylor AR. Response to comment on "Rapid Access Carotid Endarterectomy can be Performed in the Hyperacute Period without a Significant Increase in Procedural Risks" Eur J Vasc Endovasc Surg. 2011 May 30 Epub
Tambyraja AL, Fishwick NG, Bown MJ, Nasim A, McCarthy MJ, Sayers RD. Fenestrated Aortic Endografts for Juxtarenal Aortic Aneurysm: Medium Term Outcomes. Eur J Vasc Endovasc Surg. 2011 Jul 42 1 54-8
Naylor AR, Bown MJ. Stroke after Cardiac Surgery and its Association with Asymptomatic Carotid Disease: An Updated Systematic Review and Meta-analysis. Eur J Vasc Endovasc Surg. 2011 May 41 5 607-24
Bown MJ, Bolia A, Sutton AJ. Subintimal Angioplasty: Meta-analytical Evidence of Clinical Utility. Eur J Vasc Endovasc Surg. 2009 Sep 38 3 323-37
Rayt HS, Sutton AJ, London NJ, Sayers RD, Bown MJ. A Systematic Review and Meta-analysis of Endovascular Repair (EVAR) for Ruptured Abdominal Aortic Aneurysm. Eur J Vasc Endovasc Surg. 2008 Nov 36 5 536-44
Bown MJ, Braund PS, Thompson JR, London NJL, Samani NJ, Sayers RD. Association Between the Coronary Artery Disease Risk Locus on Chromosome 9p21.3 and Abdominal Aortic Aneurysm. Circ Cardiovasc Genet 2008 Oct 1 1 39-42
Franks SC, Sutton AJ, Bown MJ, Sayers RD. Systematic review and meta-analysis of 12 years of endovascular abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg. 2007 Feb 33 2 154-71
Bown MJ, Burton PR, Horsburgh T, Nicholson ML, Bell PR, Sayers RD. The role of cytokine gene polymorphisms in the pathogenesis of abdominal aortic aneurysms: a case-control study. J Vasc Surg. 2003 May 37 5 999-1005
Bown MJ, Sutton AJ, Bell PR, Sayers RD. A meta-analysis of 50 years of ruptured abdominal aortic aneurysm repair. Br J Surg. 2002 Jun 89 6 714-30
Bown MJ, Sutton AJ, Bell PR, Sayers RD. A meta-analysis of 50 years of ruptured abdominal aortic aneurysm repair. Br J Surg. 2002 Jun;89(6):714-30 (221 citations).