Dr David Adlam

Senior Lecturer

BA (Physiological Science), 1995, University of Oxford
BM BCh (Oxon) 1998
MRCP,  2001 
DPhil (Oxon) 2006

Email: da134@le.ac.uk

Address: Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield General Hospital, Leicester, LE3 9QP.

Personal details

BA, BM BCh, MRCP, DPhil

 

Publications

Key publications

  1. Adlam D, Joseph S, Robinson C, Rousseau C, Barber J, Biggs M, Morgan B, Rutty G. Coronary optical coherence tomography: minimally invasive virtual histology as part of targeted post-mortem computed tomography angiographyInt J Legal Med. 2013; 127(5): 991-6.
  2. Adlam D, Herring N, Douglas G, De Bono, JP, Li D, Danson EJ, Tatham A, Lu C-J, Casadei B, Paterson DJ, Channon KM. Regulation of β-Adrenergic Control of Heart Rate by GTP-Cyclohydrolase 1 (GCH1) and TetrahydrobiopterinCardiovasc Res. 2012; 93(4): 694-701.
  3. Adlam D, Evans N, Malhotra A, Miglani D, Rowley F, Hutchings D, Shin M, Mole G, Stockenhuber A, Wordsworth J, Lumb M, Forfar C. Repeat Percutaneous Coronary Revascularisation: Indications and Outcomes in a 'Real World' CohortCathet Card Interv. 2012; 80(4): 539-45.
  4. Adlam D*, De Bono JP*, Danson E, Zhang M, Casadei B, Paterson DJ, Channon KM. Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse modelsExp Physiol. 2011; 96(11): 1118-28. (*Joint first authors)
  5. Adlam D, Antoniades C, Lee R, Diesch J, Shirodaria C, Taggart D, Leeson P, Channon KM. OCT characteristics of saphenous vein graft atherosclerosisJACC imag. 2011; 4(7): 807-809.
  6. Adlam D, Channon KM. Radial artery graft string sign due to lumen obliteration by neointima: insight from optical coherence tomographyJACC Cardiovasc Interv. 2011; 4(5): 586-7.
  7. Adlam D, Ayers R, Channon KM. Intimal dissection causing late thrombosis of a covered stent: Optical coherence tomographyCirculation Cardiovasc Intervent. 2009; 2: 359-60.
  8. Bendall, JK, Rinze, R, Adlam, D, Tatham, AL, de Bono, J and Channon, KM. Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic miceCirc Res. 2007; 100(7): 1016-25.
  9. Adlam D*, Bendall J*, De Bono JP*, Alp NJ, Yokoyama M, Kawashima S, Channon KM. Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP Cyclohydrolase I double transgenic miceExp Physiol. 2007; 92(1): 119-26. (*Joint first authors)
  10. Bendall JK, Alp NJ, Warrick N, Cai S, Adlam D, Rockett K, Yokoyama M, Kawashima S, Channon KM.  Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo.  Insights  from transgenic mice with endothelial-targeted GTPCH and eNOS overexpressionCirc Res. 2005; 97(9): 864-71.
  11. Adlam D, Silcocks P, Sparrow N. Using BNP to develop a risk score for heart failure in primary careEur Heart J. 2005; 26(11): 1086-93.

Recent papers

  1. Jackson R, Brennan S, Fielding P, Sims MW, Challiss RA, Adlam D, Squire IB, Rainbow RD. Distinct and complementary roles for α and β isoenzymes of protein kinase C in mediating vasoconstrictor responses to acutely elevated glucoseBr J Pharmacol. 2016; 173(5): 870-87.
  2. Cheshire EC, Malcomson RD, Joseph S, Biggs MJ, Adlam D, Rutty GN. Optical clearing of the dura mater using glycerol: a reversible process to aid the post-mortem investigation of infant head injuryForensic Sci Med Pathol. 2015; 11(3): 395-404.
  3. Joseph S, Adnan A, Subhash HM, Leahy M, Adlam D. Developing cross-correlation as a method for microvessel imaging using clinical intravascular optical coherence tomography systemsBiomed Opt Express. 2015; 6(3): 668-89.
  4. Parviz Y, Iqbal J, Pitt B, Adlam D, Al-Mohammad A, Zannad F. Emerging cardiovascular indications of mineralocorticoid receptor antagonistsTrends Endocrinol Metab. 2015; 26(4): 201-11.
  5. Joseph S, Rousseau C, Subhash H. M, Leahy M. J, and Adlam D. Variation in cross-correlation as a discriminator for microvessel imaging using clinical intravascular optical coherence tomography systemsBiomed. Optical Express. 2014; 6(3): 668-689.
  6. Hadley G, Harrison P, Adlam D, Choudhury RP. 2014. Short bowel syndrome and clopidogrel non-responsiveness: a new indication for platelet aggregometry? BMJ Case Rep. 2014 Aug 12.
  7. Iqbal J, Fay R, Adlam D, Squire I, Parviz Y, Gunn J, Pitt B, Zannad F. Effect of eplerenone in percutaneous coronary intervention-treated post-myocardial infarction patients with left ventricular systolic dysfunction: a subanalysis of the EPHESUS trial. Eur J Heart Fail. 2014; 16(6): 685-91.
  8. Morgan B, Adlam D, Robinson C, Pakkal M, Rutty GN. Adult post-mortem imaging in traumatic and cardiorespiratory death and its relation to clinical radiological imaging. Br J Radiol. 2014; 87(1036): 20130662.
  9. Adlam D, Joseph S, Robinson C, Rousseau C, Barber J, Biggs M, Morgan B, Rutty G. Coronary optical coherence tomography: minimally invasive virtual histology as part of targeted post-mortem computed tomography angiography. Int J Legal Med. 2013; 127(5): 991-6.
  10. Lee R, Adlam D, Antoniades C, Digby JE, Kharbanda RK, Choudhury RP, Channon KM. Heparin administration leads to rapid decrease in plasma matrix metalloproteinase-9. Int J Cardiol. 2013; 163(2): 212-3.
  11. Adlam D, Evans N, Malhotra A, Miglani D, Rowley F, Hutchings D, Shin M, Mole G, Stockenhuber A, Wordsworth J, Lumb M, Forfar C. Repeat Percutaneous Coronary Revascularisation: Indications and Outcomes in a ‘Real World’ Cohort. Cathet Card Interv. 2012; 80(4): 539-45.
  12. Adlam D, Herring N, Douglas G, De Bono, JP, Li D, Danson EJ, Tatham A, Lu C-J, Casadei B, Paterson DJ, Channon KM. Regulation of β-Adrenergic Control of Heart Rate by GTP-Cyclohydrolase 1 (GCH1) and Tetrahydrobiopterin. Cardiovasc Res. 2012; 93(4): 494-701.
  13. Lee R, Antoniades C, Adlam D, Channon KM. Treatment of Recurrent Vein Graft "Stent-in-Stent" Restenosis Guided by Optical Coherence Tomography. Int J Cardiol. 2012; 156(1): e20-1.
  14. Adlam D*, De Bono JP*, Danson E, Zhang M, Casadei B, Paterson DJ, Channon KM. Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse models. Exp Physiol. 2011; 96(11): 1118-28. (*Joint first authors)
  15. Adlam D, Antoniades C, Lee R, Diesch J, Shirodaria C, Taggart D, Leeson P, Channon KM. OCT characteristics of saphenous vein graft atherosclerosis. JACC image. 2011; 4(7): 807-809.
  16. Inglis RG, King AJ, Gleave M, Bradlow W, Adlam D. Pericardiocentesis in contemporary practice: a study of complications by route of approach. J Invasive Cardiol. 2011; 23(6): 234-9.
  17. Adlam D, Hutchings D, Channon KM. Fourier domain Optical Coherence Tomography guided stenting of a large coronary aneurysm: images at implantation and 6-month follow-up. J Invasive Cardiol. 2011; 23(4): 168-9.
  18. King A, Adlam D, Inglis R, Hayes C, Spyrou N. A left atrial myxoma presenting as angina. N Z Med J. 2011; 124(1334): 105-6.
  19. Adlam D, Channon KM. Radial artery graft string sign due to lumen obliteration by neointima: insight from optical coherence tomography. JACC Cardiovasc Interv. 2011; 4(5): 586-7.
  20. Karia N, Adlam D, Dhunnookchand R, Sabharwal. 3-Dimensional transoesophageal echocardiography of an aberrant chordae tendinae causing aortic valvular regurgitation. Eur Heart J. 2011; 32(8): 1038.
  21. Hutchings D, Adlam D, Ferreira V, Karamitsos TD, Channon KM. Takotsubo cardiomyopathy in association with endogenous and exogenous thyrotoxicosis. QJM. 2011; 104(5): 433-5.
  22. Adlam D, Cuculi F, Lim C, Banning A. Management of spontaneous coronary artery dissection in the primary percutaneous coronary intervention era. J Invasive Cardiol. 2010; 22(11): 549-53.
  23. Adlam D, Ayers R, Channon KM. Intimal dissection causing late thrombosis of a covered stent: Optical coherence tomography. Circulation Cardiovasc Intervent. 2009; 2: 359-60.
  24. Bendall, JK, Rinze, R, Adlam, D, Tatham, AL, de Bono, J and Channon, KM. Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circ Res. 2007; 100(7): 1016-25.
  25. Adlam D*, Bendall J*, De Bono JP*, Alp NJ, Yokoyama M, Kawashima S, Channon KM. Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP Cyclohydrolase I double transgenic mice. Exp Physiol. 2007; 92(1): 119-26. (*Joint first authors)
  26. De Bono JP*, Adlam D*, Paterson DJ, Channon KM. Novel quantitative phenotypes of exercise training in mouse models. Am J Physiol Regul Integr Comp Physiol. 2006; 290(4): R926-34. (*Joint first authors)
  27. Bendall JK, Alp NJ, Warrick N, Cai S, Adlam D, Rockett K, Yokoyama M, Kawashima S, Channon KM. Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo.  Insights  from transgenic mice with endothelial-targeted GTPCH and eNOS overexpression. Circ Res. 2005; 97(9): 864-71.
  28. Adlam D, Silcocks P, Sparrow N. Using BNP to develop a risk score for heart failure in primary care. Eur Heart J. 2005; 26: 1086-1093.
  29. Azeem T, Adlam D, Gershlick A. Evolution of vascular brachytherapy: data from the RENO-registry analysis. Int J Cardiol. 2005; 100(2): 225-8.
  30. Adlam D, Azeem T, Ali T, Gershlick A. Is there a role for provocation testing to diagnose coronary artery spasm? Int J Cardiol. 2005; 102(1): 1-7.

Book chapters

  1. Adnan A and Adlam D. Coronary Artery Disease and Acute Coronary Syndrome. Chapter in: ABC of Arterial and Venous Disease, 3rd Edition. Ed T. England 2014
  2. Adlam D. The ECG in Practice. 6th Edition (Ed JR Hampton) 2014
  3. Adlam D. Coronary imaging. Chapter in: Cardiovascular Imaging. Ed Leeson P. Oxford University press 2011
  4. Adlam D, Prendergast BD. Angiography: Indications and limitations. Chapter in: Oxford textbook of interventional cardiology. Eds. Redwood S, Curzon N, Redwood M. Oxford University Press 2010
  5. Adlam D, Forfar C. Pericardial disease. Chapter in: Cardiology Medicine International Eds. Prendergast BD 2010
  6. Adlam D. Pericardial disease. Chapter in: Oxford Diagnosis and Treatment in Internal Medicine. Eds. Davey P, Sprigings D. Oxford University press 2010
  7. Adlam D.  The ECG and pacemakers, defibrillators and electrophysiology. Chapter in: The ECG in Practice 5th Edition. Ed. Hampton JR. Elsevier Ltd. 2008 (winner of the BMJ book award (cardiology) 2009.

Research

Rare coronary artery diseases

  • spontaneous coronary artery dissection (SCAD) and Coronary aneurysms and estasia (CAE)
  • Cardio-oncology
  • National data linkage studies
  • Novel medical devices
  • Coronary optical coherence tomography (including as part of minimal invasive autopsy)
  • Endocarditis

3-D OCT of coronary bifurcation stenting
3-D OCT of coronary bifurcation stenting
2-D OCT of SCAD
2-D OCT of SCAD

Research group, grants and clinical trials

Members of the Research Group

  • Dr Asif Adnan
  • Dr Abetehale Al-Hussaini
  • Ms Elham Shamsaei
  • Dr Chirag Shah
  • Dr Shiju Joseph

Clinical Trials Research

  • Add-Aspirin - Trial Management Group
  • FOURIER - Local PI
  • CATCH-AMI - Local PI
  • Global Leaders - Local PI
  • Absorb Registry - Local PI

Grants

We are grateful to our current funding sources for enabling us to carry out this research:

  • British Heart Foundation
  • NIHR
  • AstraZeneca
  • St Jude Medical
  • Sir Halley Stewart Trust

Links

Department of Cardiovascular Sciences

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