![[The University of Leicester]](unilogo.gif)
Dr David Adlam
Senior Lecturer
BA (Physiological Science), 1995, University of Oxford
BM BCh (Oxon) 1998
MRCP, 2001
DPhil (Oxon) 2006
Email: da134@le.ac.uk
Address: Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, LE3 9QP.
For general enquiries, please email the secretary Louise Goddard, or telephone 0116 258 3045.
Research Interests
- Coronary optical coherence tomography
- The role of tetrahydrobiopterin in the autonomic dysregulation of heart failure
Key Publications
Adlam D, Herring N, Douglas G, De Bono, JP, Li D, Danson EJ, Tatham A, Lu C-J, Casadei B, Paterson DJ, Channon KM. Regulation of β-Adrenergic Control of Heart Rate by GTP-Cyclohydrolase 1 (GCH1) and Tetrahydrobiopterin. Cardiovasc Res. 2012 Jan 11.
Adlam D, Evans N, Malhotra A, Miglani D, Rowley F, Hutchings D, Shin M, Mole G, Stockenhuber A, Wordsworth J, Lumb M, Forfar C. Repeat Percutaneous Coronary Revascularisation: Indications and Outcomes in a 'Real World' Cohort. Cathet Card Interv 2012 in press
Adlam D*, De Bono JP*, Danson E, Zhang M, Casadei B, Paterson DJ, Channon KM. Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse models. Exp Physiol. 2011 Nov;96(11):1118-28. (*Joint first authors)
Adlam D, Antoniades C, Lee R, Diesch J, Shirodaria C, Taggart D, Leeson P, Channon KM. OCT characteristics of saphenous vein graft atherosclerosis. JACC imag 2011 Jul;4(7): 807-809
Adlam D, Hutchings D, Channon KM. Optical Coherence Tomography guided stenting of a large coronary aneurysm: images at implantation and 6-month follow-up. J Invasive Cardiol. 2011 Apr;23(4):168-9
Adlam D, Channon KM. Radial artery graft string sign due to lumen obliteration by neointima: insight from optical coherence tomography. JACC Cardiovasc Interv. 2011 May;4(5):586-7
Adlam D, Ayers R, Channon KM. Intimal dissection causing late thrombosis of a covered stent: Optical coherence tomography. Circulation Cardiovasc Intervent 2009;2:359-60
Bendall, JK, Rinze, R, Adlam, D, Tatham, AL, de Bono, J and Channon, KM. Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice. Circ Res 2007 100(7): 1016-25
Adlam D*, Bendall J*, De Bono JP*, Alp NJ, Yokoyama M, Kawashima S, Channon KM. Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP Cyclohydrolase I double transgenic mice. Exp Physiol 2007 Jan;92(1):119-26 (*Joint first authors)
De Bono JP*, Adlam D*, Paterson DJ, Channon KM. Novel quantitative phenotypes of exercise training in mouse models. Am J Physiol Regul Integr Comp Physiol 2006 Apr;290(4):R926-34. (*Joint first authors)
Bendall JK, Alp NJ, Warrick N, Cai S, Adlam D, Rockett K, Yokoyama M, Kawashima S, Channon KM. Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo. Insights from transgenic mice with endothelial-targeted GTPCH and eNOS overexpression. Circ Res 2005 Oct 28;97(9):864-71
Adlam D, Silcocks P, Sparrow N. Using BNP to develop a risk score for heart failure in primary care. Eur Heart J. 2005 Jun;26(11):1086-93.
