NEWS
- PhD studentship available to work with Dr Peter Moody, Professor Emma Raven(Chemistry) and Dr Matthew Blakely (Institut Laue-Langevin,
Grenoble) on the structure of heme enzyme intermediates using neutron crystallography, see link - BBSRC 2011 Responsive Mode Grant, circa £316,000, awarded to Prof Geerten Vuister - "Validation of biomacromolecular structures determined by NMR spectroscopy and deposited in the Protein Data Bank"
- BBSRC 2011 Responsive Mode Grant, circa £550,000, awarded to Dr Shaun Cowley and Prof John Schwabe - "Understanding the recruitment of Class I HDACs into diverse repression complexes: implications for physiological activity and therapeutic development"
- Biochemistry PhD Student (Alice Barkell) wins UCB Celltech meeting poster prize
- Wellcome Trust Equipment Award - Dr P C E Moody, Professor's John Schwabe and Emma Raven (Chemistry)
- New approach could have a major impact on antibody engineering
- Department of Biochemistry 50th Anniversary
- Archived News
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- Info
Recent Publications
- Mazereeuw-Hautier J, Wilson LC, Mohammed S, Smallwood D, Shackleton S, Atherton DJ, Harper J. Hutchinson-Gilford Progeria syndrome: clinical findings in three patients carrying the G608G mutation in LMNA and review of the literature. British Journal of Dermatology. (In press)
- Haque F, Lloyd D, Smallwood D, Dent C, Shanahan C, Fry AM, Trembath R, Shackleton S. SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton Molecular and Cellular Biology. 26, 3738-3751
- Shackleton S, Smallwood D, Clayton P, Wilson L, Agarwal A, Garg A, Trembath R. Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype Journal of Medical Genetics. (In press)
- Lloyd D, Trembath R, Shackleton S. A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy (2002) Human Molecular Genetics 11, 769-777.
- Vigouroux C, Magré J, Vantyghem M-C, Bourut C, Lascols O, Shackleton S, Lloyd D, Guerci B, Padova G, Valensi P, Grimaldi A, Piquemal R, Touraine P, Trembath R, Capeau J. Sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy (2000) Diabetes 49, 1958-1962.
- Shackleton S, Lloyd D, Jackson S, Evans R, Niermeijer M, Singh B, Schmidt H, Brabant G, Kumar S, Durrington P, Gregory S, O'Rahilly S, Trembath R. The LMNA gene encoding lamin A/C is mutated in partial lipodystrophy (2000) Nature Genetics 24, 152-156.
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Department of Biochemistry
Henry Wellcome Building
Lancaster Road
Leicester
LE1 9HN
T: +44(0)116 229 7038
F: +44(0)116 229 7018
biochemistry@le.ac.uk
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