Current Research Interests

A current major interest in the group is understanding the structure and function of transcriptional regulatory complexes. A Wellcome Trust programme grant funds studies of the SMRT/NCoR repression complex. This complex plays an important role in the regulation of development, differentiation, cancer and homeostasis.

In addition, the group has a long standing interest in the molecular mechanisms of transcriptional regulation by nuclear receptors. Nuclear receptors are important regulators of gene expression and are major drug targets. Our understanding of the mechanism of the ligand regulated switch has been greatly enhanced by studies of the structure and dynamics of nuclear receptors.

In addition to these core research areas, the group is also involved in a number of collaborative projects with an emphasis on proteins and complexes implicated in various cancers.

Research Funding

• Wellcome Trust Programme Grant (Transcriptional Repression Complexes)
• Wellcome Trust Project Grant (Pdcd4 crystallography)
• HEFCE CIF funding for new X-ray equipment and NMR cryoplatform
• BBSRC Studentship to Robert Paskin
• EMBO Fellowship to Zsolt Czimmerer
• EMBO Fellowship to Roberta Montanari

Links to:

John Schwabe Research Highlights

John Schwabe Group Members

John Schwabe Publications