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Publications

  • A. Ababou, M. Pfuhl, J. D. Ladbury, Novel Insights into Binding Mechanisms of CIN85 SH3 Domains to Cbl Proteins: Solution based Investigations and in vivo Implications, J. Mol. Biol., 387, 1120-1136, 2009
  • Ababou A, Rostkova E, Mistry S, Le Masurier C, Gautel M, Pfuhl M. Myosin binding protein C (MyBP-C) positioned to play a key role in regulation of muscle contraction: Structure and interactions of domain C1. J. Mol. Biol. 384, 615-630, 2008
  • Ababou A, Pfuhl M, Ladbury JD. The binding stoichiometry of CIN85 SH3 domain A and Cbl-b. Nat. Struct. Mol. Biol., 15, 890-891, 2008
  • Ababou A, Gautel M, Pfuhl M. Dissecting the N-terminal myosin binding site of human cardiac myosin binding protein C: Structure and myosin binding of domain C2. J. Biol. Chem 282, 9204-9215, 2007
  • Ababou A, Zhou L, Gautel M, Pfuhl M. Sequence specific assignment of domain C1 of the N-terminal myosin binding site of Myosin Binding Protein C. J. Biomol. NMR 29, 431-432, 2004
  • Idowu SM, Gautel M, Perkins SJ, Pfuhl M. Structure, stability and dynamics of the central domain of cardiac myosin binding protein C (MyBP-C): Implications for multidomain assembly and causes for cardiomyopathy. J. Mol. Biol 329, 745-761, 2003
  • Chen HA, Pfuhl M, Driscoll PC. The pH dependence of CD2 domain 1 self-association and 15N chemical exchange broadening is correlated with the anomalous pKa of Glu41. Biochemistry 41, 14680-14688, 2002
  • Idowu CM, Gautel M, Pfuhl M. Sequence specific resonance assignment of the central domain of cardiac myosin binding protein C (MyBP-C). J. Biomol. NMR 22, 2002, 199-200
  • D. Renzoni, D. Esposito, M. Pfuhl, C. F. Higgins, P. C. Driscoll, J. E. Ladbury,
    "Structural Characterization of the Oligomerization Domain of the Bacterial Chromatin Structuring Protein H-NS", J. Mol. Biol 306, 1127-1137, 2001
  • H. A. Chen, M. Pfuhl, M. S. B. McAlister, P. C. Driscoll, "An elevated glutamate pka on the binding interface of rat CD2 domain 1", Biochemistry 39, 6814-6824, 2000
  • D. Esposito, P. C. Driscoll, M. Pfuhl, "NMR of natural macromolecules". Royal Society of Chemistry, Specialist Periodical Reports, ed G. A. Webb, vol 29, 340-396, 2000
  • M. Pfuhl, P. C. Driscoll, "Protein nuclear magnetic resonance in the next millenium",review article, Philosophical Transactions of the Royal Society A, millenium issue 3, Chemistry and biological physics, Vol 358, 513-546, 2000
  • M. Pfuhl, H. A. Chen, S. M. Kristensen,  P. C. Driscoll, "NMR exchange broadening arising from specific low affinity protein self-association: Analysis of nitrogen-15 nuclear relaxation for rat CD2 domain 1", J. Biomol. NMR 14,307-320, 1999
  • M. S. B. McAlister, B. Davis, M. Pfuhl, P. C. Driscoll, "NMR analysis of the N-terminal SRCR domain of human CD5: engineering of a glycoprotein for superior characteristics in NMR experiments", Prot. Eng. 11, 847-853, 1998
  • H. A. Chen, M. Pfuhl, B. Davis, P. C. Driscoll, "Sequence specific 1H, 13C
    and 15N resonance assignment of rat CD2 domain 1", J. Biomol. NMR  12, 457-458, 1998
  • J. Pascual, M. Pfuhl, D. Walter, M. Saraste, M. Nilges, "Solution structure of the spectrin repeat: a Left-handed Antiparallel Triple-helical Coiled-coil ", J. Mol. Biol.  273, 740-751, 1997
  • M. Pfuhl, S. Improta, A. S. Politou, A. Pastore, "When a module is also
    a domain: The importance of the N-terminus in the dynamics and the
    stability of Immunoglobulin domains from Titin.", J. Mol. Biol. 265, 242-256, 1997
  • M. Ubbink, M. Pfuhl, J. v.d. Oost, A. Berg, G. W. Canters,
    "NMR Assignments and relaxation studies of Thiobacillus Versutus cytochrome  c-550 indicate the presence of a highly mobile 13-residue long C-terminal tail.", Protein Science 5, 2494-2505, 1996
  • J. Pascual, M. Pfuhl, G. Rivas, A. Pastore, M. Saraste, "The spectrin repeat
    folds into a compact three-helix structure in solution", FEBS Letters 383, 201-207, 1996 
  • M. Pfuhl, S. J. Winder, M.-A. Castiglione-Morelli, S. Labeit, A. Pastore, "Correlation Between Conformational and Binding Properties of Nebulin Repeats", J. Mol. Biol. 257, 367-384, 1996
  • G. Trave, P.-J. Lacombe, M. Pfuhl, M. Saraste, Annalisa Pastore,
    "Molecular mechanism of the calcium-induced conformational change in the spectrin EF-hands", EMBO J. 14, 4922-4931, 1995
  • M. Gautel, M. A. Castiglione-Morelli, M. Pfuhl, A. Motta, A. Pastore, "A calmodulin binding sequence in the C-terminus of human cardiac titin kinase", Eur. J. Biochem. 230, 752-759, 1995
  • Pfuhl, A. Pastore, "Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I-set", Structure  3, 391-401, 1995
  • M. Pfuhl, M. Gautel, A. S. Politou, C. Joseph, A. Pastore, "Secondary
    structure determination by NMR spectroscopy of an immunoglobulin domain of the giant muscle protein titin", J. Biomol. NMR 5, 48-58, 1995
  • M. Pfuhl, F. Fogolari, G. Esposito, P. Viglino, A. Pastore, "A 3D Experiment to Observe Collective Modes", Quarterly of Magnetic  Resonance in Biology and Medicine 1, 53-60, 1994
  • A.S. Politou, M. Gautel, M. Pfuhl, S. Labeit, A. Pastore, "Immunoglobulin-Type Domains of Titin: Same Fold, Different stability ?", Biochemistry  33, 4730-4737, 1994
  • M. Pfuhl, S. J. Winder, A. Pastore, "Nebulin, a helical actin binding protein", EMBO J. 13, 1782-1789, 1994

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biochemistry@le.ac.uk