NEWS
- PhD studentship available to work with Dr Peter Moody, Professor Emma Raven(Chemistry) and Dr Matthew Blakely (Institut Laue-Langevin,
Grenoble) on the structure of heme enzyme intermediates using neutron crystallography, see link - BBSRC 2011 Responsive Mode Grant, circa £316,000, awarded to Prof Geerten Vuister - "Validation of biomacromolecular structures determined by NMR spectroscopy and deposited in the Protein Data Bank"
- BBSRC 2011 Responsive Mode Grant, circa £550,000, awarded to Dr Shaun Cowley and Prof John Schwabe - "Understanding the recruitment of Class I HDACs into diverse repression complexes: implications for physiological activity and therapeutic development"
- Biochemistry PhD Student (Alice Barkell) wins UCB Celltech meeting poster prize
- Wellcome Trust Equipment Award - Dr P C E Moody, Professor's John Schwabe and Emma Raven (Chemistry)
- New approach could have a major impact on antibody engineering
- Department of Biochemistry 50th Anniversary
- Archived News
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- Info
Publications
- Wagner T, Bellinzoni M, Wehenkel A, O'Hare HM, Alzari PM. Functional plasticity and allosteric regulation of alpha-ketoglutarate decarboxylase in central mycobacterial metabolism. Chem Biol. 2011 18: 1011-20.
- Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ. An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis. Sci Signal. 2009 Mar 24;2(63):ra12.
- O’Hare HM, Durán R, Cerveñansky C, Bellinzoni M, Wehenkel AM, Pritsch O, Obal G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM. Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol. 2008 Dec;70(6):1408-23.
- O'Hare HM, Juillerat A, Dianiskova P, Johnsson K. A split-protein sensor for studying protein-protein interaction with mycobacteria. J Microbiol Methods 2008;73:79-84
- Sacco E, Suarez A, O'Hare HM, Carroll P, Eynard N et al. The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. PNAS 2007;104:14628-33
- O'Hare HM, Johnsson K, Gautier A. Chemical probes shed light on protein function. Curr Opin Struct Biol 2007;17:488-494
- O'Hare HM, Choroba OW, Spencer JB. Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution. FEBS Letts 2006;580:3445-50
- O'Hare HM, Baerga-Ortiz A, Popovic B, Spencer JB, Leadlay PF. Highthroughput mutagenesis of polyketide ketoreductases reveals a model for stereochemical control. Chem Biol 2006;13:287-96
- Baerga-Ortiz A, Popovic B, Siskos AP, O'Hare HM et al. Identification of active site residues that control the stereospecificity of a ketoreductase domain from a modular polyketide synthase. Chem Biol 2006;13:277-285
- Bali S, O'Hare HM, Weissmann KJ. Broad substrate specificity of ketoreductases derived from modular polyketide synthases. Chembiochem 2006;7:478-84
- O'Hare HM, Johnsson J. The laboratory ina droplet. Chem Biol 2005;12:1255-7
- Cohen HM, Griffiths AD, Tawfik DS, Loakes D. Determinants of cofactor binding to DNA methyltransferases: insights from a systematic series of structural variants of s-adenosylhomocysteine. Org Biomol Chem 2005;3:152-61
- Cohen HM, Tawfik DS, Griffiths AD. Altering the sequence specificity of HaeIII methyltransferase by directed evolution using in vitro compartmentalisation. Protein Eng Des Sel 2004;17:3-11
- Cohen HM, Tawfik DS, Griffiths AD. Promiscuous methylation of non-canonical DNA sites by HaeIII methyltransferase. Nucleic Acids Res 2002;30:3880-5
- Konfortov BK, Cohen HM, Bankier AT, Dear PH. A high-resolution HAPPY map of Dictyostelium discoideum chromosome 6. Genome Res 2000;10:1737-42.
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Department of Biochemistry
Henry Wellcome Building
Lancaster Road
Leicester
LE1 9HN
T: +44(0)116 229 7038
F: +44(0)116 229 7018
biochemistry@le.ac.uk
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