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Henry Wellcome Laboratories of Structural Biology
The Henry Wellcome Laboratories of Structural Biology have state of the art facilities for macromolecular structure determination and the analysis of macromolecular interactions and function.
Research Groups
| Prof. Mark Carr | Prof. Gordon Roberts |
| Dr. Peter Moody | Dr. Ralf Schmid |
| Prof. Geerten Vuister | Dr Richard Bayliss |
| Prof. John Schwabe | Dr Cyril Dominguez |
Senior Experimental Officers
| Dr Fred Muskett | Facility Manager |
| Dr Khushwant Sidhu | Computer Manager |
Research Areas
- Macromolecular Crystallography
The crystallography facility is equipped with robotics for protein crystallisation and visualisation and a state of the art X-ray generator and detector.
Current research interests include:
- Transcriptional factors and complexes
- Glycolytic enzymes
- Heme binding proteins (enzymes and regulatory factors)
- Cytoskeletal proteins
... and many others
-
NMR
The NMR facility is equipped for studies of macromolecular structure and interactions in solution. It has one 500MHz, two 600MHz and one 800MHz NMR spectrometers.
Current research interests include:
- Microbial virulence factors
- Transcriptional regulators
- Cell-signalling factors
- Cytoskeletal proteins
... and many others
The Bioinformatics and Computational Biology group has expertise in diverse fields of bioinformatics such as protein structure prediction and fold recognition, molecular modelling and docking, sequence and phylogenic analysis.
