![[The University of Leicester]](unilogo.gif)
Neuroscience Journal Club
Announcements for the Neuroscience & Behaviour Theme Journal Club for postgraduate students and post-docs
James Sinclair will present his paper:
Central neurons respond to synaptic inputs from other neurons by generating synaptic potentials. Once the summated synaptic potentials reach threshold for action potential firing, the signal propagates leading to transmitter release at the synapse. The calcium influx accompanying such signaling opens calcium-activated ion channels for feedback regulation. Here, we report a mechanism for modulating hippocampal neuronal signaling that involves calcium-activated chloride channels (CaCCs). We present evidence that CaCCs reside in hippocampal neurons and are in close proximity of calcium channels and NMDA receptors to shorten action potential duration, dampen excitatory synaptic potentials, impede temporal summation, and raise the threshold for action potential generation by synaptic potential. Having recently identified TMEM16A and TMEM16B as CaCCs, we further show that TMEM16B but not TMEM16A is important for hippocampal CaCC, laying the groundwork for deciphering the dynamic CaCC modulation of neuronal signaling in neurons important for learning and memory.
Wendy C. Huang, Shaohua Xiao, Fen Huang, Brian D. Harfe, Yuh Nung Jan, Lily Yeh Jan,
Neuron, Volume 74, Issue 1, 12 April 2012, Pages 179-192, ISSN 0896-6273, 10.1016/j.neuron.2012.01.033.
Previous meetings
| 10/5/12 | Tom Nielson |
Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Abrahamsson T, Cathala L, Matsui K, Shigemoto R, Digregorio DA. Neuron. 2012 Mar 22;73(6):1159-72. Epub 2012 Mar 21. |
| 12/4/12 | Thomas Tagoe |
Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity. Mitra A, Mitra SS, Tsien RW |
| 29/3/12 | Joanna Shaw |
Acute Cannabinoids Impair Working Memory through Astroglial CB(1) Receptor Modulation of Hippocampal LTD. Han J, Kesner P, Metna-Laurent M, Duan T, Xu L, Georges F, Koehl M, Abrous DN, Mendizabal-Zubiaga J, Grandes P, Liu Q, Bai G, Wang W, Xiong L, Ren W, Marsicano G, Zhang X.Cell. 2012 Mar 2;148(5):1039-50. |
| 15/3/12 | Hana Smeda |
Tomas Ondrejcak, Qinwen Wang, James N.C. Kew, David J. Virley, Neil Upton, Roger Anwyl, Michael J. Rowan: Activation of α7 nicotinic acetylcholine receptors persistently enhances hippocampal synaptic transmission and prevents Aß-mediated inhibition of LTP in the rat hippocampus. European Journal of Pharmacology, Volume 677, Issues 1–3, Pages 63–70 |
| 1/3/12 | Vanessa Keasberry | Autry et al (2011) NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475: 91–9 |
| 9/2/12 | Albert Okorocha | Functional evidence for D-serine inhibition of non-N-methyl-D-aspartate ionotropic glutamate receptors in retinal neurons. European Journal of Neuroscience, Vol. 35, pp. 56–65, 2012 |
| 19/1/12 | Chris Stubbendorff | Disentangling pleasure from incentive salience and learning signals in brain reward circuitry. Proc Natl Acad Sci U S A. 108(27), E255-64 (2011). |
| 15/12/11 | Rodrigo Bammann |
The smallest insects evolve anucleate neurons. Arthropod Structure & Development Volume 41, 29-34 (2012). |
| 1/12/11 | Thomas Tagoe |
Sustained firing of cartwheel cells in the dorsal cochlear nucleus evokes endocannabinoid release and retrograde suppression of parallel fiber synapses. J Neurosci. 31(44), 15807-17 (2011). |
| 10/11/11 | Jim Sinclair |
Onset of Cholinergic Efferent Synaptic Function in Sensory Hair Cells of the Rat Cochlea. Journal of Neuroscience 31(42), 15092-15101 (2011). |
| 13/10/11 | Tom Nielson |
Attention-like deficit and hyperactivity in a Drosophila memory mutant. J Neurosci. 30(3):1003-14 (2010). |
| 22/9/11 | Rodrigo Bammann |
Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation. Nature Neuroscience 14, 688–690 (2011) |
| 18/8/11 | Volko Straub |
Caiazzo M et al: Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature (2011) 476(7359):224-7. |
| 28/7/11 | Tom Tagoe | T Tzounopoulos et al: Coactivation of Pre- and Postsynaptic Signaling Mechanisms Determines Cell-Specific Spike-Timing-Dependent Plasticity Neuron. 2007 April 19; 54(2): 291–301. |
| 7/7/11 | Ria Cooke |
Maria Papadopoulou et al: Normalization for Sparse Encoding of Odors by a Wide-Field Interneuron. Science 6 May 2011: Vol. 332 no. 6030 pp. 721-725 |
| 23/6/11 | Adam Tozer |
D Fioravante et al: Calcium-Dependent Isoforms of Protein Kinase C Mediate Posttetanic Potentiation at the Calyx of Held. Neuron, Volume 70, Issue 5, 1005-1019, 9 June 2011 |
| 26/5/11 | Tom Nielsen |
Peled & Isacoff Nature Neurosci 2011 Apr;14(4):519-26 |
| 6/4/11 | Joanna Shaw |
Sung Hyun Kim & Timothy A. Ryan. Neuron (2010) Volume 67 (5): 797-809. |
| 24/3/11 | Rodrigo Bammann |
Ede A Rancz et al "Transfection via whole-cell recording in vivo: bridging single-cell physiology, genetics and connectomics". Nature Neuroscience (2011) Advance online publications |
| 10/3/11 | Asha Akram |
Li et al "The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury." J. Neurochem. (2010) 113, 965-977 |
| 22/2/11 | Volko Straub |
Kravitz et al, "Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry" Nature. 2010 Jul 29;466(7306):622-6. |
| 10/2/11 | Thomas Tagoe |
Johansen et al, "Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray." Nat Neurosci. 2010 Aug;13(8):979-86. |
| 27/1/11 | Tom Nielsen |
Ha et al, "Functional Organization of a Neural Network for Aversive Olfactory Learning in Caenorhabditis elegans" Neuron. 2010 Dec 22;68(6):1173-86 |
