Synthetic Approaches to Cancer Chemical Biology
The Group research interests in the area of chemical biology are focused on a number of projects relevant to cancer and other medically important areas. These projects have in common the synthesis of biologically active molecules and, en route, the development of new synthetic methods. Many of these projects exploit our expertise in the syntheses of a broad range of functionalized heterocyclic compounds.
Current projects include:
- Design and synthesis of small molecule probes and inhibitors of the spliceosome (with Prof Eperon, Biochemistry).
- Sythesis of heterocyclic inhibitors of protein kinases (with Profs Cullis and Pritchard)
- Synthesis and biological activity of novel glycosidase inhibitors based on azasugars.
Techniques and expertise:
- Heterocyclic chemistry
- Stereo-controlled organic syntheses
- High Field NMR spectroscopic analysis of small molecules
- HPLC analysis and purification