Mechanisms and principles of regulation of gene expression

There is a large cohort of researchers in the theme who have an interest either in unravelling the mechanisms through which gene expression is regulated, or exploring the mechanisms through which gene regulation controls biological processes. These studies include the understanding the structure of the nuclear envelope (Shackleton); the organisation of chromosomes and chromatin (Heslop-Harrison, Schwarzacher); the regulation of transcription by transcription factors and epigenetic controls (Barlev, Carr, Cowley, Schwabe); regulation of splicing and choice of alternative splicing pathways (Eperon, Makarova, Dominguez); regulation of translation (Herbert, Schaffrath, Willis) and ultimately how these regulation mechanisms dictate development and other biological pathways (Twell, Drea, Wagner, Burke, Cowley, Rosato).

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