Laboratory for Synaptic Imaging

A central theme of the research carried out in this laboratory is the cellular mechanisms of memory storage. Memory is thought to be encoded as long lasting changes in the strength of signalling between synapses formed by excitable cells in the brain. By gaining a better understanding of the mechanisms responsible for memory acquisition, we aim to improve our ability to enhance the brains capacity to learn and develop strategies for repair following injury or neurodegenerative diseases that affect memory, such as Alzheimer’s disease.

One of the models of synaptic plasticity that we study is the long-term depression of transmission at the synapse formed between cerebellar granule cells and Purkinje cells. So called LTD may provide the mechanism for learning in the motor system, allowing acquisition of skilled movements during development and practice. Over the last few years, we have examined the contributions of numerous receptors and second messengers to LTD and other forms of plasticity at this synapse, including calcium, nitric oxide, cyclic AMP, cyclic GMP and arachidonic acid.

We are currently working towards developing methods of visualising transmitter release and receptor trafficking using fluorescent protein based sensors. Our long term goal is to to be able to visualise synapses "learning". We are in the process of developing a high speed random access confocal micrsocope that we will use to examine the activity of cells within complex neuronal circuits. You can find out more about our current research here.

We would like to thank the BBSRC and the Royal Society for their continued, generous support.